Abstract | AIMS: To evaluate prevalence of primary Helicobacter pylori antibiotic resistances in Northeast Italy and to identify risk factors associated with this resistance. MATERIALS AND METHODS: A total of 248 patients undergoing upper gastrointestinal endoscopy were enrolled from 19 Endoscopy Units over a 6-month period. From each patient, 4 gastric biopsies were taken for histology and 2 were sent to the Central Referral Microbiological Laboratory for culture and determination of antibiotic activity against Helicobacter pylori by means of E-test. Strains were considered resistant when minimum inhibitory concentration was >8 microg/ml for metronidazole and >1 microg/ml for clarithromycin. No cut-off value was predefined for amoxycillin. RESULTS: Culture of Helicobacter pylori was successfully performed in 167 patients. Primary resistance to metronidazole, clarithromycin or amoxycillin was 14.9%, 1.8% and 0%, respectively Patients infected with Helicobacter pylori strains resistant to antibiotics were more frequently females than males (70.3% vs 41.4%), had a significantly lower coffee intake (66.6% vs 86.6%) and lower body mass index (23.7+/-2.6 vs 25.3+/-3.6) than patients with susceptible Helicobacter pylori strains. Age, smoking, alcohol use, family history of Helicobacter pylori infection, concomitant diseases and treatments, endoscopic diagnoses, Helicobacter pylori density and histological activity of chronic gastritis were not associated with antibiotic resistance. Multivariate analysis confirmed that female gender (odds ratio = 2.74, 95% confidence interval = 1.03-7.27) was the only significant risk factor associated with antibiotic resistance. CONCLUSIONS:
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Authors | A Pilotto, M Rassu, G Leandro, M Franceschi, F Di Mario, Interdisciplinary Group for the Study of Ulcer |
Journal | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
(Dig Liver Dis)
Vol. 32
Issue 9
Pg. 763-8
(Dec 2000)
ISSN: 1590-8658 [Print] Netherlands |
PMID | 11215555
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study)
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Chemical References |
- Anti-Bacterial Agents
- Metronidazole
- Amoxicillin
- Clarithromycin
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Topics |
- Adult
- Aged
- Amoxicillin
(pharmacology)
- Anti-Bacterial Agents
(pharmacology)
- Biopsy, Needle
- Clarithromycin
(pharmacology)
- Confidence Intervals
- Culture Techniques
- Drug Resistance, Microbial
- Female
- Gastritis
(drug therapy, epidemiology, microbiology, pathology)
- Gastroscopy
- Helicobacter Infections
(diagnosis, drug therapy, epidemiology)
- Helicobacter pylori
(drug effects, isolation & purification)
- Humans
- Italy
(epidemiology)
- Male
- Metronidazole
(pharmacology)
- Microbial Sensitivity Tests
- Middle Aged
- Multivariate Analysis
- Prevalence
- Probability
- Risk Factors
- Sex Distribution
- Statistics, Nonparametric
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