Comparison of the expression of ABH/Lewis-related antigens in polypoid and non-polypoid growth types of colorectal carcinoma.

Abstract

BACKGROUND AND AIMS:

Colorectal tumors can be classified based on their growth pattern into the polypoid growth-type (PG-type) and non-polypoid growth-type (NPG-type). To ascertain whether there is any relationship between the expression of particular blood group-related antigens (A, B, H, Lewis (Le)a, sialyl Le(a), Le(x), sialyl Le(x)) in a colorectal tumor, and a tumor having polypoid or non-polypoid growth, we examined 78 PG-type and NPG-type colorectal cancers.

METHODS:

Fourteen PG-type and 64 NPG-type colorectal carcinomas were subjected to immunohistochemical analyses by using monoclonal antibodies against A, B, H, Le(a), sialyl Le(a), Le(x) and sialyl Le(x).

RESULTS:

The patients with NPG-type carcinomas had a significantly younger age of onset, significantly smaller maximal tumor diameter, significantly higher rate of lymph node metastasis and significantly worse prognosis than those with PG-type carcinomas. Among the 32 tumors of patients with blood type A or AB, isoantigen A was expressed in a significantly larger percentage of NPG-type carcinomas than PG-type carcinomas (95.8 vs 62.5%, respectively; P=0.014). Among all 78 tumors, sialyl Le(x) antigen was expressed in a significantly larger percentage of NPG-type than PG-type carcinomas (90.6 vs 64.3%, respectively; P=0.010). Multivariate analysis using the logistic regression model revealed that isoantigen A and sialyl Le(x) expression were independent predictive risk factors for the development of NPG-type colorectal carcinoma.

CONCLUSIONS:

These data suggest that the expression of isoantigen A and sialyl Le(x) in a colorectal carcinoma partially determines whether the tumor will have polypoid or non-polypoid growth.

• Authors: T Nakagoe, K Fukushima, A Nanashima, T Sawai, T Tsuji, M A Jibiki, H Yamaguchi, T Yasutake, H Ayabe, T Matuo, Y Tagawa
• Journal: Journal of gastroenterology and hepatology (J Gastroenterol Hepatol) Vol. 16 Issue 2 Pg. 176-83 (Feb 2001) ISSN: 0815-9319 [Print] Australia
• PMID: 11207898 (Publication Type: Comparative Study, Journal Article)

Chemical References

• ABO Blood-Group System
• Isoantigens
• Lewis Blood Group Antigens

Topics

• ABO Blood-Group System (physiology)
• Aged
• Colonic Polyps (blood, physiopathology)
• Colorectal Neoplasms (blood, classification, physiopathology)
• Female
• Humans
• Isoantigens (blood)
• Lewis Blood Group Antigens (physiology)
• Male
• Middle Aged
• Multivariate Analysis
• Predictive Value of Tests
• Regression Analysis
• Risk Factors