Abstract | OBJECTIVE: MATERIALS AND METHODS: RESULTS: CONCLUSIONS: Immunostaining for TTF-1, especially when combined with immunostaining for CK20, can aid in the distinction between Merkel cell carcinoma and small cell carcinoma (both pulmonary and extrapulmonary). However, in individual cases, these markers cannot be used to distinguish between pulmonary and extrapulmonary small cell carcinomas due to the extensive overlap in immunophenotypes.
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Authors | W Cheuk, M Y Kwan, S Suster, J K Chan |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 125
Issue 2
Pg. 228-31
(Feb 2001)
ISSN: 0003-9985 [Print] United States |
PMID | 11175640
(Publication Type: Journal Article)
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Chemical References |
- Intermediate Filament Proteins
- KRT20 protein, human
- Keratin-20
- NKX2-1 protein, human
- Nuclear Proteins
- Thyroid Nuclear Factor 1
- Transcription Factors
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Topics |
- Carcinoma, Merkel Cell
(chemistry, diagnosis)
- Carcinoma, Small Cell
(chemistry, diagnosis, pathology)
- Diagnosis, Differential
- Digestive System Neoplasms
(chemistry, diagnosis)
- Female
- Genital Neoplasms, Female
(chemistry, diagnosis)
- Humans
- Intermediate Filament Proteins
(analysis)
- Keratin-20
- Lung Neoplasms
(chemistry, diagnosis, pathology)
- Male
- Nuclear Proteins
(analysis)
- Prostatic Neoplasms
(chemistry, diagnosis)
- Skin Neoplasms
(chemistry, diagnosis, pathology)
- Thyroid Nuclear Factor 1
- Transcription Factors
(analysis)
- Urinary Bladder Neoplasms
(chemistry, diagnosis)
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