Abstract | BACKGROUND: METHODS: RESULTS: One hundred and fifty-seven patients (32%) had no nephropathy, 104 (21%) incipient nephropathy, 126 (25%) established nephropathy and 107 (22%) advanced nephropathy. There was a significant relationship between the stages of diabetic nephropathy and TC (P=0.002), TG (P<0.0001), Apo B (P=0.0007) or Lp(a) (P=0. 038), but not Apo A1. However the genetic polymorphism distributions of LPL, CETP and Apo epsilon did not differ in terms of renal complications. The study power to reject the null hypothesis was 58% for the Apo epsilon genotypes. CONCLUSION: These results support no or only marginal effects of a genetic basis for lipid disturbances encountered in diabetic nephropathy.
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Authors | S Hadjadj, Y Gallois, G Simard, B Bouhanick, P Passa, A Grimaldi, P Drouin, J Tichet, M Marre |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 15
Issue 12
Pg. 1971-6
(Dec 2000)
ISSN: 0931-0509 [Print] England |
PMID | 11096142
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Apolipoproteins E
- CETP protein, human
- Carrier Proteins
- Cholesterol Ester Transfer Proteins
- Glycoproteins
- Lipids
- Lipoprotein Lipase
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Topics |
- Adult
- Apolipoproteins E
(genetics)
- Carrier Proteins
(genetics)
- Cholesterol Ester Transfer Proteins
- Chronic Disease
- Cohort Studies
- Diabetes Mellitus, Type 1
- Diabetic Nephropathies
(blood, genetics)
- Female
- Genotype
- Glycoproteins
- Humans
- Lipids
(blood)
- Lipoprotein Lipase
(genetics)
- Male
- Middle Aged
- Polymorphism, Genetic
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