Prognostic markers in patients with typical bronchial carcinoid tumors.

Abstract

Typical bronchial carcinoids are usually considered fairly benign tumors. Metastases do however occur, and up to 10% of the patients ultimately die from their disease. To identify prognostic markers, we immunostained 43 typical bronchial carcinoids with antibodies against 8 possibly relevant hormones, oncogenes, tumor suppressor genes, adhesion molecules, and proliferation markers. Altogether 12 patients (28%) had metastatic disease, of whom 10 had regional lymph node metastases at diagnosis. Distant metastases have occurred in 5 patients (12%); all of these have died from their disease. Patients with high expression of Ki-67 had shorter survival time (P < 0.01). None of the immunostained hormones correlated to distant metastases or shorter survival time, but gastrin-releasing peptide correlated to metastatic disease (P < 0.05). All patients who died had CD44-negative tumors (P < 0.001). Nuclear nm23 staining correlated to decreased risk for metastatic disease and distant metastases per se (P < 0.01). Bcl-2 and p53 were associated with increased risk for distant metastases (P < 0.05 and P < 0.01, respectively). We conclude that some patients with typical bronchial carcinoids die from their disease and that gastrin-releasing peptide, Bcl-2, and p53 may be of importance for the malignant transformation of the tumor. Moreover, CD44, nm23, and Ki-67 may give valuable prognostic information and help identify the patients at risk of disease-related death.

• Authors: D Granberg, E Wilander, K Oberg, B Skogseid
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 85 Issue 9 Pg. 3425-30 (Sep 2000) ISSN: 0021-972X [Print] United States
• PMID: 10999844 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Growth Substances
• Hormones
• Hyaluronan Receptors

Topics

• Adolescent
• Adult
• Aged
• Apoptosis (physiology)
• Biomarkers, Tumor
• Bronchial Neoplasms (diagnosis, metabolism, pathology)
• Carcinoid Tumor (diagnosis, metabolism, pathology)
• Female
• Genes, Tumor Suppressor (genetics)
• Growth Substances (blood)
• Hormones (blood)
• Humans
• Hyaluronan Receptors (blood)
• Immunohistochemistry
• Male
• Middle Aged
• Oncogenes (genetics)
• Prognosis
• Survival Analysis