[A clinical study of secondary osteoporosis induced by endocrine therapy for prostate cancer].

Abstract

PURPOSE:

There is one of the big problems that endocrine therapy for prostate cancer causes to induce secondary osteoporosis. The risk factors and future treatments for osteoporosis were investigated.

MATERIALS AND METHODS:

31 patients treated with luteinizing hormone releasing hormone agonists (LHRH-a) or combination of chlormadinone acetate (CMA) and LHRH-a, and 19 patients with no treatments for prostate cancer were included in the analysis. Lumber spine bone mineral density (BMD) was measured by quantitative computed tomography.

RESULTS:

Aging had much influence on decreases of BMD than the other risk factors (p < 0.01). There were statistically decreases of BMD in the patients with CMA + LHRH-a compared with no treatments (p < 0.05). Adrenal androgen which had an important role of maintenance in BMD was statistically decreased by the administration of CMA (p < 0.01).

CONCLUSIONS:

Measurement of BMD before endocrine therapy is necessary for the patients with prostate cancer. It is important for the patients with decreases of BMD that CMA is not combined or the therapy for osteoporosis is preventively employed.

• Authors: A Furuta, S Yanada, A Takizawa, S Iwamuro, M Suzuki, K Tashiro, T Hatano, Y Oishi
• Journal: Nihon Hinyokika Gakkai zasshi. The japanese journal of urology (Nihon Hinyokika Gakkai Zasshi) 2000 Jul-Aug Vol. 91 Issue 7-8 Pg. 573-8 ISSN: 0021-5287 [Print] Japan
• PMID: 10965741 (Publication Type: English Abstract, Journal Article)

Chemical References

• Androgens
• Antineoplastic Agents, Hormonal
• Chlormadinone Acetate
• Gonadotropin-Releasing Hormone

Topics

• Aged
• Aged, 80 and over
• Aging
• Androgens (metabolism)
• Antineoplastic Agents, Hormonal (adverse effects)
• Bone Density (drug effects)
• Chlormadinone Acetate (adverse effects)
• Gonadotropin-Releasing Hormone (adverse effects, agonists)
• Humans
• Male
• Osteoporosis (chemically induced)
• Prostatic Neoplasms (drug therapy)
• Risk Factors