Is Campylobacter lipopolysaccharide bearing a GD3 epitope essential for the pathogenesis of Guillain-Barré syndrome?

Abstract

The hypothesis has been proposed that the GD3 ganglioside-like lipopolysaccharide (LPS) is essential for and functions in the development of Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) subsequent to Campylobacter jejuni enteritis. Our study showed that patients with GBS or MFS who had previously suffered diarrhea had anti-GD3 antibodies less often than those who had not had diarrhea. Sera from patients who showed GBS or MFS with the serologic evidence of prior C. jejuni infection had anti-GD3 antibodies less frequently than sera from those without evidence of infection. Statistical analysis showed that anti-GD3 antibodies were less frequent in patients with GBS or MFS from whom C. jejuni had been isolated than were other antiganglioside antibodies, such as anti-GM1 antibodies. These results could not support the above hypothesis.

• Authors: N Yuki, M Koga, K Hirata
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 102 Issue 2 Pg. 132-4 (Aug 2000) ISSN: 0001-6314 [Print] Denmark
• PMID: 10949532 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Epitopes
• Gangliosides
• Immunoglobulin G
• Lipopolysaccharides
• ganglioside, GD3

Topics

• Acute Disease
• Antibodies, Bacterial (blood)
• Campylobacter Infections (complications, immunology, microbiology)
• Campylobacter jejuni (immunology, isolation & purification)
• Case-Control Studies
• Diarrhea (etiology, immunology)
• Epitopes
• Female
• Gangliosides (immunology)
• Gastroenteritis (complications, immunology, microbiology)
• Guillain-Barre Syndrome (etiology, immunology, microbiology)
• Humans
• Immunoglobulin G
• Lipopolysaccharides (immunology)
• Male
• Miller Fisher Syndrome (immunology, microbiology)