Influenza in three patients with human immunodeficiency virus infection.

Abstract

Three Japanese outpatients with human immunodeficiency virus (HIV) infection on anti-retroviral therapy showed evidence of influenza in January 1999. CD4+ T cell counts of these patients prior to the diagnosis of influenza were 72, 248, and 152/mm3, and HIV RNA levels were 19,953, 1,259, and 1,585 copies/ml, respectively. Fever continued 4 to 5 days with no severe complications. One patient showed post-influenzal bronchitis which was effectively treated by antibiotics. None of these patients showed increased serum HIV RNA levels during and after influenza, however, in one patient, a transient reduction of CD4+ and CD8+ cells was seen during the active phase of influenza. Although symptoms of influenza in HIV carriers are generally mild and similar to those in healthy adults, careful follow-up is needed as symptoms of influenza in some HIV-infected patients can be prolonged and serious.

• Authors: S Nabeshima, I Ariyama, Y Chong, K Hirotsu, K Kakuda, J Hayashi, S Kashiwagi
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 39 Issue 7 Pg. 592-7 (Jul 2000) ISSN: 0918-2918 [Print] Japan
• PMID: 10888219 (Publication Type: Case Reports, Journal Article)

Chemical References

• Influenza Vaccines
• RNA, Viral

Topics

• AIDS-Related Opportunistic Infections (immunology)
• Adult
• Antiretroviral Therapy, Highly Active
• CD4 Lymphocyte Count
• CD8-Positive T-Lymphocytes
• Female
• HIV Infections (complications, drug therapy, immunology)
• Humans
• Influenza A virus
• Influenza Vaccines
• Influenza, Human (etiology, immunology)
• Lymphocyte Count
• Male
• RNA, Viral (blood)