Role of infection control measures in limiting morbidity associated with multi-resistant organisms in critically ill patients.

Abstract

A retrospective comparative study was performed to determine the impact of infection control measures (ICMs) on colonization and infections due to methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae (producing transferable extended-spectrum beta-lactamase, KPESBL), and multi-resistant Enterobacter aerogenes (MREA) in intensive care unit patients. Infection Control Measures included surveillance cultures, isolation procedures and mupirocin for MRSA nasal carriage. The numbers of patients infected and/or colonized by MRSA, KPESBL or MREA were compared during two consecutive one-year periods (Period 1 before ICMs, and Period 2 after ICMs). The antibiotic consumption during the two periods was analysed. In Period 1 and Period 2, respectively, the rate of patients infected or colonized by at least one of the three organisms was 15% and 6.8% (P=0.001); by MRSA 7.7% and 2.6% (P=0. 004); by KPESBL 1.7% and 0% (P=0.25); and by MREA 5.6% and 4.3% (P=0. 47). During Period 2, there was a clear-cut decrease in the percentage of patients infected by MRSA (P=0.018), a non-significant decrease in those infected by KPESBL (P=0.06), and no decrease in patients infected by MREA (P=0.22). When calculated per 1000 patient-days, for Period 1 and Period 2, respectively, the rate of patients infected or colonized by at least one of the three organisms was 11.9 and 8.8; for MRSA it was 4 and 2.2; for KPESBL it was 1 and 0; and for MREA it was 4 and 4. Antibiotic cost was pound98.7 in Period 1 and pound62.7 in Period 2. ICMs contributed to the control of infections and colonizations due to MRSA and KPESBL but not those due to MREA.

• Authors: B Souweine, O Traore, B Aublet-Cuvelier, L Bret, J Sirot, H Laveran, P Deteix
• Journal: The Journal of hospital infection (J Hosp Infect) Vol. 45 Issue 2 Pg. 107-16 (Jun 2000) ISSN: 0195-6701 [Print] England
• PMID: 10860687 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright 2000 The Hospital Infection Society.

Chemical References

• Anti-Bacterial Agents

Topics

• Aged
• Anti-Bacterial Agents (economics, therapeutic use)
• Bacterial Infections (microbiology, prevention & control)
• Drug Costs
• Drug Resistance, Multiple
• Enterobacteriaceae Infections (epidemiology, prevention & control)
• Female
• France (epidemiology)
• Humans
• Infection Control (methods)
• Intensive Care Units
• Klebsiella Infections (epidemiology, prevention & control)
• Klebsiella pneumoniae
• Male
• Methicillin Resistance
• Retrospective Studies
• Staphylococcal Infections (epidemiology, prevention & control)
• beta-Lactam Resistance