T102C polymorphism of the serotonin (5-HT) 2A receptor gene in patients with non-fatal acute myocardial infarction.

Abstract

Serotonin (5-HT), released from activated platelets, has been implicated in the pathogenesis of acute myocardial infarction (AMI). 5-HT induces platelet aggregation and vascular contraction through 5-HT2A receptor activation at sites of coronary atherosclerosis, leading to thrombus formation. Recently, a 5-HT2A receptor gene T102C polymorphism has been reported to be associated with clinical response to 5-HT2A receptor antagonist in patients with schizophrenia, suggesting this polymorphism of the gene affects the 5-HT2A receptor function. To investigate the relationship between the T102C polymorphism and AMI, we conducted a case-control study of 255 non-fatal AMI patients and 255 control subjects. Among the patients, the prevalence of TT genotype was significantly higher than in controls (32.5 vs. 24.3%; P<0.05). In male patients (n=216), the prevalence was much higher than in control subjects (33.8 vs. 24. 1%, P<0.03). In multiple logistic regression models, odds ratio of TT genotype was 1.45 (95% CI 0.96-2.20) in all and 1.61 (95% CI 1. 03-2.53) (P<0.05) in males. The association of T102C polymorphism of the 5-HT2A receptor gene with non-fatal AMI was statistically significant and independent of other risk factors in males. The TT genotype of the 5-HT2A receptor gene may enhance susceptibility to AMI. Our observations suggest that the T102C polymorphism of the 5-HT2A receptor gene can serve as a new genetic marker for AMI.

• Authors: S Yamada, H Akita, K Kanazawa, T Ishida, K Hirata, K Ito, S Kawashima, M Yokoyama
• Journal: Atherosclerosis (Atherosclerosis) Vol. 150 Issue 1 Pg. 143-8 (May 2000) ISSN: 0021-9150 [Print] Ireland
• PMID: 10781645 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptor, Serotonin, 5-HT2A
• Receptors, Serotonin

Topics

• Aged
• Alleles
• Case-Control Studies
• Female
• Genotype
• Humans
• Logistic Models
• Male
• Middle Aged
• Myocardial Infarction (genetics)
• Odds Ratio
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Receptor, Serotonin, 5-HT2A
• Receptors, Serotonin (genetics)
• Risk Factors