Abstract | OBJECTIVE: DESIGN AND SUBJECTS: Within the framework of the WHO-MONICA project, a population study composed of 1195 subjects aged 35-64 y was randomly sampled from the electoral rolls of the urban community of Lille, in northern France. Subjects receiving medical treatment for hypercholesterolemia, hypertension or diabetes mellitus were excluded for the analyses, to avoid any interferences between medical treatment and biological variables. This resulted in a sample size of 839 subjects (421 men/418 women, age=49.4+/-8.1 y, body mass index (BMI)=25.7+/-4.4 kg/m2). To evaluate the role of the Pro12Ala polymorphism in the onset of NIDDM, we evaluated its distribution in 170 Caucasian NIDDM subjects from a clinical series (117 men/53 women, age=62.3+/-9.0 y, BMI=30.1+/-3.6 kg/m2). MEASUREMENTS: RESULTS: In the WHO-MONICA population, the Ala allele frequency was 0.11. The presence of the Ala allele was significantly associated with higher body weight (P=0.002), BMI (P=0.02), height (P=0.02) and waist circumference (P=0.04). Increased plasma concentrations of total cholesterol (P=0.01), LDL-cholesterol (P=0.004) and apolipoprotein B (P=0.01) were also detected in Ala allele bearers. The distribution of the Pro12Ala polymorphism was similar in NIDDM subjects (Ala allele frequency: 0.10) and in the WHO-MONICA population subjects. CONCLUSION: Our results suggest that genetic variability of PPARgamma2 affects body weight control and lipid homeostasis in humans and do not support a significant role for the PPARgamma2 Pro12Ala polymorphism in the aetiology of NIDDM. International Journal of Obesity (2000) 24, 195-199
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Authors | A Meirhaeghe, L Fajas, N Helbecque, D Cottel, J Auwerx, S S Deeb, P Amouyel |
Journal | International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
(Int J Obes Relat Metab Disord)
Vol. 24
Issue 2
Pg. 195-9
(Feb 2000)
England |
PMID | 10702770
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- DNA Primers
- Receptors, Cytoplasmic and Nuclear
- Transcription Factors
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Topics |
- Adult
- Alleles
- Body Mass Index
- DNA Primers
- Diabetes Mellitus, Type 2
(genetics)
- Female
- France
- Gene Frequency
- Humans
- Hyperlipidemias
(genetics)
- Male
- Middle Aged
- Obesity
(genetics)
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, Cytoplasmic and Nuclear
(genetics)
- Transcription Factors
(genetics)
- White People
(genetics)
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