Prevention of chromosomal aberration in mouse bone marrow by indole-3-carbinol.

Abstract

In this study, we report the protective effect of indole-3-carbinol (I3C), one of the glucobrassicin derivative isolated from cruciferous vegetables against cyclophosphamide induced chromosomal aberrations in mouse bone marrow cells. The three test doses namely 1000,500 and 250 mg/kg b.wt. of I3C provided protection when given 48 h prior to the single i.p. administration of cyclophosphamide (50 mg/kg). I3C alone did not induce chromosomal aberrations at the test doses of 1000 and 500 mg/kg b.wt.. Thus tested glucobrassicin derivative seems to have a preventive potential against cyclophosphamide induced chromosomal aberrations in Swiss mouse bone marrow cells at the doses tested.

• Authors: R C Agrawal, S Kumar
• Journal: Toxicology letters (Toxicol Lett) Vol. 106 Issue 2-3 Pg. 137-41 (Jun 01 1999) ISSN: 0378-4274 [Print] Netherlands
• PMID: 10403657 (Publication Type: Journal Article)

Chemical References

• Antimutagenic Agents
• Indoles
• indole-3-carbinol

Topics

• Animals
• Antimutagenic Agents (pharmacology)
• Bone Marrow (drug effects, ultrastructure)
• Chromosome Aberrations
• Dose-Response Relationship, Drug
• Indoles (pharmacology)
• Male
• Mice