[Serum eosinophil cationic protein, urinary eosinophil protein X and urinary N-methylhistamine during acute asthma in children].

Abstract

Serum eosinophil cationic protein (ECP), urinary eosinophil protein X (EPX) and urinary N-methylhistamine were investigated in 24 asthmatic children during acute asthma to determine the sequential variation in the parameters. Serum ECP levels and urinary EPX levels were high during acute asthma, and decreased gradually with improvement of acute asthma, however, these levels of eosinophil drived proteins were significantly higher than those in non-atopic children. There was no significant variation of urinary NMH levels. Significant inverse correlation was found between lung function and urinary EPX level. The present study suggests that serum ECP and urinary EPX may be useful for monitoring airway inflammation during acute asthma, and activation of eosinophils may persist after improvement of acute asthma.

• Authors: S Shirakawa, E Iwasaki, Y Miyabayashi, M Baba
• Journal: Arerugi = [Allergy] (Arerugi) Vol. 47 Issue 12 Pg. 1240-7 (Dec 1998) ISSN: 0021-4884 [Print] Japan
• PMID: 10028717 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers
• Blood Proteins
• Eosinophil Granule Proteins
• Methylhistamines
• Eosinophil-Derived Neurotoxin
• Ribonucleases
• N-methylhistamine

Topics

• Acute Disease
• Adolescent
• Asthma (blood, urine)
• Biomarkers (analysis)
• Blood Proteins (analysis)
• Child
• Eosinophil Granule Proteins
• Eosinophil-Derived Neurotoxin
• Eosinophils (physiology)
• Female
• Humans
• Male
• Methylhistamines (urine)
• Ribonucleases