Hyperlactatemia

Increase in blood LACTATE concentration often associated with SEPTIC SHOCK; LUNG INJURY; SEPSIS; and DRUG TOXICITY. When hyperlactatemia is associated with low body pH (acidosis) it is LACTIC ACIDOSIS.

Also Known As:

Networked: 709 relevant articles (24 outcomes, 54 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hyperkalemia
2.	Sepsis (Septicemia)
3.	Critical Illness (Critically Ill)
4.	Septic Shock (Toxic Shock Syndrome)
5.	Lactic Acidosis

Experts

1.	Bellomo, Rinaldo: 11 articles (10/2017 - 08/2002)
2.	Castro, Ricardo: 8 articles (12/2017 - 08/2011)
3.	Kattan, Eduardo: 8 articles (12/2017 - 01/2012)
4.	Bruhn, Alejandro: 8 articles (01/2016 - 08/2011)
5.	Bakker, Jan: 7 articles (01/2021 - 09/2010)
6.	Radermacher, Peter: 7 articles (10/2017 - 08/2003)
7.	Hernandez, Glenn: 7 articles (01/2017 - 08/2011)
8.	Epstein, Steven E: 6 articles (01/2022 - 03/2014)
9.	Hopper, Kate: 6 articles (01/2022 - 03/2014)
10.	Cardellach, Francesc: 5 articles (12/2015 - 11/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperlactatemia:

1.	Lactic Acid (Lactate)FDA LinkGeneric 11/01/2023 - "Hyperlactatemia, a problem reported in up to 30% of cardiac surgery patients, results from excessive production of or decreased clearance of lactate. " 08/01/2004 - "In the group with elevated lactate at baseline, symptoms of hyperlactatemia improved in 8% to 23% of patients, did not change in 69%, and worsened in 8%. " 12/01/2022 - "The aim of this study is to investigate the incidence and non-lactate risk factors for ICU mortality in hyperlactatemia patients who underwent CRRT. " 05/01/2022 - "In this study, we aimed to document the development of severe hyperlactatemia in acute situations among patients with and without DM, to analyze potential contributors to lactate elevation and their impact on mortality, and to analyze whether lactate concentrations of >4 mmol/L have equal prognostic significance in patients with and without DM. " 01/01/2021 - "This study is the first to show that perioperative hyperlactatemia and decreased lactate clearance may be predictors for occurrence of CDI after cardiac surgery."
2.	NucleosidesIBA 10/01/2006 - "Although not rare, hyperlactatemia was not related to short-term exposure to nucleoside analog antiretroviral regimens." 11/01/2004 - "In our series, almost half of the children (63 of 127) who were exposed to nucleoside analogues developed benign and self-limited hyperlactatemia. " 07/01/2000 - "Hyperlactatemia and hepatic abnormalities in 10 human immunodeficiency virus-infected patients receiving nucleoside analogue combination regimens." 11/21/2003 - "Safety and efficacy of switching to alternative nucleoside analogues following symptomatic hyperlactatemia and lactic acidosis." 08/15/2007 - "We describe 24 Ugandan patients with human immunodeficiency virus infection who developed symptomatic hyperlactatemia associated with the use of nucleoside analogues. "
3.	Reverse Transcriptase InhibitorsIBA 08/15/2007 - "Symptomatic hyperlactatemia associated with nucleoside analogue reverse-transcriptase inhibitor use in HIV-infected patients: a report of 24 cases in a resource-limited setting (Uganda)." 01/01/2007 - "Unrecognized near-fatal hyperlactatemia in an HIV-infected infant exposed to nucleoside reverse transcriptase inhibitors." 11/01/2005 - "Treatment with nucleoside reverse-transcriptase inhibitors (NRTIs) is associated with hyperlactatemia, presumably as a result of NRTI-induced mitochondrial toxicity. " 09/01/2003 - "Symptom-free hyperlactatemia was observed in HIV-infected children receiving nucleoside analog reverse transcriptase inhibitors. " 02/01/2002 - "Hyperlactatemia associated with use of nucleoside analogue reverse transcriptase inhibitors (NRTIs) is not a single entity but a spectrum of abnormalities. "
4.	Oxygen (Dioxygen)IBA 03/01/2020 - "Some small observational studies have found that a Pcv-aCO2/Ca-cvO2 > 1.4 was associated with hyperlactatemia, oxygen supply dependency, and increased mortality. " 01/01/2020 - "Four hours after PICU admission, 62% of the patients had hyperlactatemia (>2 mmol/L), of whom 55% had normal oxygen extraction (SaO2-SvO2 < 30%). " 03/01/2019 - "hyperlactatemia) in the ED, and 2) number of patients who received fluids and oxygen in the ambulance. " 03/01/2018 - "Although the most common cause of hyperlactatemia is inadequate tissue oxygen delivery, hyperlactatemia can, and does occur in the face of apparently adequate oxygen supply. " 01/01/2017 - "Irrespective of the cause, the presence of hyperlactatemia should trigger a search for remedial causes of impaired tissue oxygenation, bearing in mind that normal-or even supranormal-indices of global oxygen delivery may exist despite regional tissue hypoperfusion."
5.	Carbon DioxideIBA 05/25/2023 - "                The study aimed to investigate the relationship between the respiratory quotient (RQ), measured by the central venous-arterial carbon dioxide partial pressure difference/arterial-venous oxygenation difference ratio, and the early remission of multi-organ failure (MOF) in sepsis patients with hyperlactatemia. " 06/01/2006 - "The present study is aimed to identify the possible predictors of hyperlactatemia during CPB among a series of oxygen and carbon dioxide derived parameters measured during CPB. " 01/01/2022 - "Ten minutes after partial exchange transfusion, oxygen uptake and carbon dioxide production measured by indirect calorimetry suddenly dropped, while the respiratory quotient began to rise steeply before hyperlactatemia developed a few hours later. " 05/20/2015 - "The Use of the Ratio between the Veno-arterial Carbon Dioxide Difference and the Arterial-venous Oxygen Difference to Guide Resuscitation in Cardiac Surgery Patients with Hyperlactatemia and Normal Central Venous Oxygen Saturation." 08/01/2017 - "Persistent hyperlactatemia-high central venous-arterial carbon dioxide to arterial-venous oxygen content ratio is associated with poor outcomes in early resuscitation of septic shock."
6.	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 04/01/2022 - "The aim of our present study is to evaluate the efficacy and safety of RCA versus LMWH for CRRT in hyperlactatemia patients. " 04/01/2022 - "Adult patients with hyperlactatemia who underwent RCA or LMWH CRRT in our center between January 2014 and March 2018 were retrospectively recruited. " 04/01/2022 - "Regional citrate anticoagulation versus low molecular weight heparin for CRRT in hyperlactatemia patients: A retrospective case-control study." 04/01/2022 - "There were controversial opinions on the use of regional citrate anticoagulation (RCA) versus low molecular weight heparin (LMWH) for continuous renal replacement therapy (CRRT) in hyperlactatemia patients, which was considered as one of the contraindications of citrate. " 04/01/2022 - "In critically ill patients with hyperlactatemia requiring CRRT, RCA is superior to LMWH in terms of filter lifespan and bleeding risk without significantly increased risk of citrate accumulation and citrate related metabolic complications. "
7.	Glucose (Dextrose)FDA LinkGeneric 01/01/2007 - "glucose turnover may contribute to hyperlactatemia. " 01/01/1999 - "Our results show that hyperlactatemia decreased glucose uptake in muscles (i.e., red quadriceps; P < 0.05). " 05/01/1984 - "The effects of hyperlactatemia on cerebral glucose metabolism of normoglycemic 20-day-old rats were studied in animals breathing air or 20% CO2:21% O2:59% N2. " 01/01/2022 - "Lymphoma total lesion glycolysis leads to hyperlactatemia and reduction of brain glucose utilization." 01/01/2009 - "AVP increased the rate of direct, aerobic glucose oxidation and reduced hyperlactatemia, which coincided with less severe kidney dysfunction and liver injury, attenuated systemic inflammation, and decreased kidney tubular apoptosis. "
8.	Pyruvic Acid (Pyruvate)IBA 01/12/2021 - "An increase of glycolysis pathway leading to pyruvate escalation is the mechanism of hyperlactatemia in β2-adrenergic agonist drug. " 02/01/1980 - "Altered metabolism of pyruvate is central to the development of lactic acidosis and hyperlactatemia. " 07/01/2000 - "Simultaneous elevation of lactate to pyruvate ratio (L/P ratio) may be helpful in discriminating between different mechanisms of hyperlactatemia and thus in determining the relevance of the finding. " 01/01/2019 - "Differentiating Hyperlactatemia Type A From Type B: How Does the Lactate/pyruvate Ratio Help?" 05/01/2004 - "While liver O(2) delivery and uptake remained unchanged, HMR induced hyperlactatemia [from 1.5 (1.1; 2.0), 1.4 (1.2; 1.8), and 1.2 (0.8; 2.0) to 3.1 (1.4; 3.2), 3.2 (1.6; 6.5), and 3.0 (1.0; 5.5) mmol/l in the arterial, portal and hepatic venous samples, respectively] and further increased arterial [from 8 (3; 13) to 23 (11; 57); p<0.05], portal [from 9 (4; 14) to 23 (14; 39); p<0.05] and hepatic vein [from 7 (0; 15) to 30 (8; 174), p<0.05] lactate/pyruvate ratios indicating impaired cytosolic redox state. "
9.	Indicators and Reagents (Reagents)IBA 04/01/1997 - "An elevated anion gap is not a sensitive indicator of moderate hyperlactatemia, but it is quite specific, provided the other main causes of the elevated anion gap have been eliminated. " 03/01/1984 - "In individual patients, hyperlactatemia is a useful indicator pointing to the severity of illness and to superimposed complications. " 08/01/2022 - "Hyperlactatemia as a prognostic indicator for contemporary left ventricular assist device implantation." 01/01/2022 - "Furthermore, the ratio between the pCO2 gap and p(v-a)CO2/C(a-v)O2 may be a promising indicator of anaerobic metabolism, allowing for the identification of different causes of tissue hypoxia and hyperlactatemia. " 10/01/2012 - "Although hyperlactatemia is an important indicator of sepsis and impaired tissue perfusion, caution is required when performing such an assessment in patients being administered Glyceol(®)."
10.	AlbuminsIBA 08/01/2021 - "Sustained reduction in heart rate and hyperlactatemia (p < 0.001) was better in the albumin group. " 12/16/2008 - "Base deficit (BD), anion gap (AG), and albumin corrected anion gap (ACAG) are used by clinicians to assess the presence or absence of hyperlactatemia (HL). " 03/01/2008 - "Anion gap, anion gap corrected for albumin, and base deficit do not predict the presence or absence of clinically significant hyperlactatemia. " 03/01/2008 - "The receiver-operating characteristic area under the curve for the prediction of hyperlactatemia for anion gap, anion gap corrected for albumin, and base deficit were 0.55, 0.57, and 0.64, respectively. " 01/01/2023 - "In multivariate analysis, vitamin D deficiency (odds ratio [OR], 2.43; 95 % confidence interval [CI], 1.03-5.74), hyperlactatemia (OR, 3.65; 95 % CI, 1.95-6.83), Sequential Organ Failure Assessment scores (OR, 1.22; 95% CI, 1.09-1.36), and albumin levels (OR, 0.39; 95% CI, 0.21-0.73) were significantly associated with 30-day mortality. "

Therapies and Procedures

1.	Resuscitation 05/25/2023 - "The study observed 49 septic patients with hyperlactatemia in the ICU, obtaining blood samples before and after resuscitation, and dividing the patients into two groups depending on whether the modified Sequential Organ Failure Assessment score improved after 24 hours of treatment. " 12/13/2022 - "Since LR easily led to hyperlactatemia, its resuscitation effect was limited. " 12/01/2017 - "However, clinical recognition of different sources of hyperlactatemia is unfortunately not a common practice and patients are treated with the same strategy despite the risk of over-resuscitation in some. " 01/01/2017 - "In addition, non-hypoxic sources can be involved in hyperlactatemia, and a misinterpretation could lead to over-resuscitation in an unknown number of cases. " 12/01/2021 - "Initial fluid resuscitation of 30 mL/kg within 3 or 6 h was neither associated with an increased or decreased in-hospital mortality in septic shock patients with isolated hyperlactatemia."
2.	Drug Therapy (Chemotherapy) 09/01/2018 - "Patient was refractory to standard chemotherapy regimen showing life-threatening hyperlactatemia. " 03/11/2020 - "Hematopoietic malignancy with hyperlactatemia has a very poor prognosis; however, hyperlactatemia and impaired consciousness were dramatically improved in this patient by critical care management and chemotherapy." 03/16/2023 - "Here, we describe a case of hyperlactatemia during the postoperative resection of liver metastases after chemotherapy for sigmoid colon cancer. " 01/01/1992 - "This hyperlactatemia and hyperinsulinemia did not improve when dogs with lymphoma were put into remission with doxorubicin chemotherapy. " 03/11/2020 - "However, his impaired consciousness and hyperlactatemia did not improve until after the start of chemotherapy with doxorubicin, cyclophosphamide, vincristine, prednisolone, and rituximab. "
3.	Renal Replacement Therapy (Therapies, Renal Replacement) 01/01/2022 - "Control of the triggering condition is the most effective treatment of hyperlactatemia, but since this is mostly not readily possible, extracorporeal renal replacement therapy (RRT) is often tried as a last resort. " 01/01/2022 - "Increasing age and Sequential Organ Failure Assessment score, Clinical Frailty Scale score greater than or equal to 4, use of mechanical ventilation, vasopressors, renal replacement therapy, and hyperlactatemia were risk factors for death in a multivariable analysis. " 04/01/2014 - "Symptoms gradually improved and false hyperlactatemia resolved after renal replacement therapy and fomepizole administration. "
4.	Highly Active Antiretroviral Therapy (HAART) 01/15/2014 - "Prolonged exposure to highly active antiretroviral therapy (HAART) is associated with adverse effects such as hyperlactatemia. " 12/01/2009 - "HIV and HAART-related hyperlactatemia is associated with a general mitochondrial impairment which reverts after recovery. " 12/01/2009 - "We obtained lymphocytes and monocytes of 26 HIV-infected and treated patients who developed hyperlactatemia and after recovery, 28 nonhyperlactatemic HIV subjects on HAART, 31 naive individuals, and 20 uninfected controls. " 12/01/2009 - "Genetic and functional mitochondrial assessment of HIV-infected patients developing HAART-related hyperlactatemia." 11/01/2003 - "Our findings support the hypothesis that MRC dysfunction stands at the basis of HAART-related hyperlactatemia."
5.	Critical Care (Surgical Intensive Care) 05/24/2020 - "Frequency of Hyperlactatemia in Intensive Care Patients within Tertiary Care Hospital in Pakistan." 01/01/2015 - "In cardiac critical care, hyperlactatemia is usually multifactorial in origin, resulting from a combination of etiologies. " 01/01/2009 - "We sought to determine the occurrence and relation of hyperlactatemia with ICU mortality in all patients admitted to four ICUs in a large regional critical care system. " 10/01/2006 - "Patients with hyperlactatemia required longer intensive care and postoperative ventilatory support. " 05/24/2020 - "Objective The aim of this study is to determine the frequency of hyperlactatemia in intensive care patients with sepsis in Civil Hospital Karachi. "