Steroid Synthesis Inhibitors

Compounds that bind to and inhibit enzymes involved in the synthesis of STEROIDS.

Also Known As:

Adrenal Steroid Synthesis Inhibitors; Androgen Synthesis Inhibitors; Estrogen Synthesis Inhibitors; Glucocorticoid Synthesis Inhibitors; Mineralocorticoid Synthesis Inhibitors; Progestin Synthesis Inhibitors; Sex Hormone Synthesis Inhibitors; Steroid Synthesis Antagonists; Steroid Synthesis Blockers; Antagonists, Steroid Synthesis; Blockers, Steroid Synthesis; Inhibitors, Androgen Synthesis; Inhibitors, Estrogen Synthesis; Inhibitors, Glucocorticoid Synthesis; Inhibitors, Mineralocorticoid Synthesis; Inhibitors, Progestin Synthesis; Inhibitors, Steroid Synthesis; Synthesis Antagonists, Steroid; Synthesis Blockers, Steroid; Synthesis Inhibitors, Androgen; Synthesis Inhibitors, Estrogen; Synthesis Inhibitors, Glucocorticoid; Synthesis Inhibitors, Mineralocorticoid; Synthesis Inhibitors, Progestin; Synthesis Inhibitors, Steroid

Networked: 24 relevant articles (5 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Enzyme Inhibitors: 1659
      - Steroid Synthesis Inhibitors: 24
        Aromatase Inhibitors: 4565
        5-alpha Reductase Inhibitors: 307
        14-alpha Demethylase Inhibitors: 18
  - Physiological Effects of Drugs: 1
    - Hormones, Hormone Substitutes, and Hormone Antagonists
      - Hormone Antagonists: 38
        Steroid Synthesis Inhibitors: 24
        Aromatase Inhibitors: 4565
        5-alpha Reductase Inhibitors: 307
        14-alpha Demethylase Inhibitors: 18

Experts

1.	Ryan, Charles J: 2 articles (01/2020 - 12/2014)
2.	Rennie, Paul S: 2 articles (12/2016 - 07/2015)
3.	Grigoryev, D N: 2 articles (12/2000 - 12/2000)
4.	Long, B J: 2 articles (12/2000 - 12/2000)
5.	Agarwal, Neeraj: 1 article (07/2022)
6.	Goel, Divyam: 1 article (07/2022)
7.	L Maughan, Benjamin: 1 article (07/2022)
8.	Li, Haoran: 1 article (07/2022)
9.	Nordblad, Blake: 1 article (07/2022)
10.	Nussenzveig, Roberto H: 1 article (07/2022)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 05/01/2014 - "Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer." 07/31/2020 - "Despite the administration of androgen synthesis inhibitors and chemotherapy regimens for castration-resistant prostate cancer, the treatment options for this entity are limited. " 01/01/2013 - "Here, we review the discovery and clinical development of abiraterone and other novel androgen-synthesis inhibitors for the management of advanced prostate cancer." 12/01/2000 - "Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer." 05/01/2013 - "Although the treatment of castration-resistant prostate cancer (CRPC) has benefited from the use of increasingly potent androgen synthesis inhibitors and androgen receptor (AR) antagonists, it is only marginally effective. "
2.	Neoplasms (Cancer) 06/01/2017 - "Androgen receptor (AR) splice variants have been clinically associated with progressive cancer, castration-resistance, and resistance to AR antagonists and androgen synthesis inhibitors. " 12/01/2000 - "These findings suggest that some prostate cancer patients who appear to become hormone-independent may have tumors which are stimulated by P(5) via a mutated AR and that these patients could benefit from treatment with antiestrogens, antiprogestins, or with some of our novel androgen synthesis inhibitors." 05/20/2022 - "The presence of an androgen synthesis, independent of CYP17A1 activity, has been shown to exist in prostate cancer cells, and thus, novel androgen synthesis inhibitors are needed for the treatment of enzalutamide-resistant CRPC tumors that do not respond to abiraterone."
3.	Hypertension (High Blood Pressure) 01/01/2023 - "Androgen synthesis inhibitors are associated with increased rates of hypertension, atrial tachyarrhythmia, and, in rare incidences, heart failure. " 07/07/2015 - "Androgen synthesis inhibitors induced significant increases in risk ratios for adverse effects linked to elevated mineralocorticoid secretion, compared to placebo (risk ratio for hypokalemia: 5.75, 95% CI 2.08 to 15.90; P = 0.0008; risk-ratio for hypertension: 2.29, 95% CI 1.02 to 5.17; P = 0.05). "
4.	Pituitary ACTH Hypersecretion 02/01/2003 - "Steroid synthesis inhibitors are commonly used in the treatment of patients with Cushing's disease, but may also improve psychopathology in hypercortisolemic depressed patients. "
5.	Tachycardia (Tachyarrhythmias) 01/01/2023 - "Androgen synthesis inhibitors are associated with increased rates of hypertension, atrial tachyarrhythmia, and, in rare incidences, heart failure. "

Related Drugs and Biologics

1.	Androgen Antagonists (Antiandrogens)
2.	Androgen Receptors (Androgen Receptor)
3.	enzalutamide
4.	abiraterone
5.	Ketoconazole (Nizoral)
6.	Estrogens (Estrogen)
7.	Androgens
8.	Androgen Receptor Antagonists
9.	Gonadotropin-Releasing Hormone (GnRH)
10.	Hormones (Hormone)

Related Therapies and Procedures

1.	Castration
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)