Desoxycorticosterone Acetate (DOCA)

The 21-acetate derivative of desoxycorticosterone.

Also Known As:

DOCA; DOC-21-acetate; Deoxycorticosterone-21-acetate; Desoxycorticosterone-21-acetate; Desoxycortone Acetate; Syncortyl; Acetate, Desoxycortone; DOC 21 acetate; Deoxycorticosterone 21 acetate; Desoxycorticosterone 21 acetate

Networked: 1743 relevant articles (83 outcomes, 258 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Fink, Gregory D: 28 articles (01/2019 - 02/2002)
2.	Watts, Stephanie W: 23 articles (01/2016 - 02/2002)
3.	Galligan, James J: 19 articles (01/2018 - 02/2002)
4.	Brown, Lindsay: 14 articles (01/2016 - 02/2002)
5.	Duarte, Juan: 11 articles (08/2021 - 03/2004)
6.	Osborn, John W: 10 articles (01/2019 - 10/2005)
7.	Chen, Alex F: 10 articles (05/2012 - 02/2002)
8.	Malinowska, Barbara: 9 articles (10/2021 - 04/2016)
9.	Jiménez, Rosario: 9 articles (08/2021 - 04/2004)
10.	Kim, Soo Wan: 9 articles (01/2013 - 04/2002)

Related Diseases

1.	Hypertension (High Blood Pressure) 06/01/1990 - "The results of this study indicate that only the combination of 1% NaCl in tap water and DOCA administration is effective in accelerating hypertension in adult SHR. " 05/01/2017 - "Based on the similarity in the anatomic characteristics of renal artery between pigs and humans, this study was undertaken to establish a low-dose sustained-release DOCA-induced hypertension model in pigs. " 11/01/2009 - "These studies indicate that an activated renal dopaminergic system attenuates the development of hypertension, at least in large part through activating medullary COX-2 expression/activity, and also decreases oxidative stress resulting from DOCA/HS." 11/01/1996 - "In conclusion, the present data suggests that STZ-DOCA model may not be considered as the ideal model for the study of cardiovascular complications of combined treatment hypertension and diabetes. " 01/01/1996 - "Electron microscopy study of different diameter and functional purpose mesenterial arteries revealed that spontaneous and DOCA-saline hypertension cause different ultrastructural changes in all coats with the exception of cranial mesenterial artery, in endotheliocytes of which no changes occurred in spontaneous hypertension. "
2.	Fibrosis (Cirrhosis) 01/01/2018 - "Interstitial and perivascular fibrosis occurred in response to DOCA, but perivascular fibrosis was greater in aging mice. " 01/01/2014 - "The severity of myocardial fibrosis and PVCA/VA ratio in DOCA+IMA group were markedly lower than those in DOCA group although they were higher than those in CON group. " 01/01/2014 - "At days 28, the severity of myocardial fibrosis and PVCA/VA ratio in DOCA group were significantly increased when compared with CON group. " 05/01/2012 - "ALI can inhibit the DOCA induced myocardial fibrosis independent of its pressure-lowing effect, which may be related to the suppression of RA and Ang II production, inhibition of ERK1/2 phosphorylation and MMP9 expression in the heart." 04/01/2012 - "DOCA + Ang II induced cardiac damage as assessed by heart weight, cardiac fibrosis as well as expression of fetal and matrix components but no significant difference was found between CCR5(-/-) and WT mice. "
3.	Inflammation (Inflammations) 01/01/2019 - "It is demonstrated that the Hep-DOCA conjugate and PVAX are synthesized successfully; PVAX and Hep-DOCA nanodrugs (HDP) are obtained by co-assembly; the HDP nanoparticles effectively reduce the inflammation and coagulation without inducing lethal bleeding both in vivo and in vitro. " 11/13/2021 - "Mechanically, rhFGF21 induced AMPK activation in DOCA-salt-treated mice and PA-stimulated HK-2 cells, which inhibited NF-κB-regulated inflammation and Nrf2-mediated oxidative stress and thus, is important for rhFGF21 protection against DOCA-salt-induced nephropathy. " 01/01/2018 - "The current study tested the hypothesis that TRDNx and ARDNx would similarly decrease mean arterial pressure (MAP) in the DOCA-salt hypertensive rat, and only TRDNx would mitigate renal inflammation. " 01/01/2019 - "In Experiment 2, the contribution of renal nerves in renal inflammation was assessed in a 2-kidney DOCA-salt rat to control for renal perfusion pressure. " 12/01/2016 - "These data suggest that afferent renal nerve activity may mediate the hypertensive response to DOCA salt, but inflammation may be mediated primarily by efferent renal sympathetic nerve activity. "
4.	Cardiomegaly (Heart Hypertrophy) 01/01/2022 - "LV transcriptome analysis showed a molecular cardiac hypertrophy/remodeling signature in WT but not KO mice with significant upregulation of 1234 transcripts, including Cpxm2, in response to DOCA. " 08/01/2009 - "After 6 weeks DOCA, Gas 6(-/-) mice developed similar telemetric blood pressure elevations compared to wild-type mice but were protected from cardiac hypertrophy. " 09/01/2002 - "The DOCA and DOCA+L-NAME groups showed relative renal and cardiac hypertrophy, which was not observed in the DOCA+L-NAME+prazosin group. " 01/01/1982 - "The degree of cardiomegaly in ALA and DOCA rats was statistically much greater than the differences in their respective blood pressure levels when compared to controls. " 09/01/1979 - "Both 19-nor-DOCA-treated groups rapidly became hypertensive and developed cardiac hypertrophy, as did those given DOCA and saline. "
5.	Hypertrophy 01/01/2020 - "TNFα deficiency improved EDR and lowered cardiac and vascular hypertrophy with a mild reduction in SBP (152 ± 4 vs. 167 ± 5 mmHg in DOCA group, p < 0.05) in DOCA mice. " 10/11/2016 - "TAC/DOCA cRbm20ΔRRM-DMSO mice developed LV hypertrophy and a marked increase in LV chamber stiffness as shown by both pressure-volume analysis and echocardiography. " 08/01/2015 - "In conclusion, Ang-(1-7) protective signaling against DOCA-induced diastolic dysfunction occurs independently of BP attenuation and is mediated by the activation of pathways involved in Ca(2+) handling, hypertrophy, and survival. " 09/01/2011 - "EO significantly decreased arterial blood pressure and heart rate along with cardiac and renal hypertrophy in a dose-dependent fashion as compared to DOCA control rats. " 02/01/1998 - "The percentage of V3 isomyosin in hearts with hypertrophy from aortic banding or administration of desoxycorticosterone acetate was increased compared with the control groups. "

Related Drugs and Biologics

1.	Salts
2.	Desoxycorticosterone (Deoxycorticosterone)
3.	Acetates (Acetic Acid Esters)
4.	Proteins (Proteins, Gene)
5.	Messenger RNA (mRNA)
6.	Glucose (Dextrose)
7.	Hexamethonium (Hexamethonium Bromide)
8.	Collagen Type I (Type I Collagen)
9.	Sodium
10.	Desoxycorticosterone Acetate (DOCA)

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Intraperitoneal Injections
4.	Intravenous Infusions
5.	Drug Therapy (Chemotherapy)