Cryogels

Macroporous hydrogels that are produced at subzero temperatures. Cryogels have pores that are produced by growing ice crystals and have been developed with a tissue-like elasticity that is suitable for cell immunization experiments.

Also Known As:

Networked: 185 relevant articles (9 outcomes, 28 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kumar, Ashok: 18 articles (01/2022 - 01/2005)
2.	Bencherif, Sidi A: 6 articles (01/2022 - 08/2015)
3.	Guo, Baolin: 5 articles (02/2022 - 01/2018)
4.	Werner, Carsten: 5 articles (11/2021 - 01/2017)
5.	Savina, Irina N: 5 articles (06/2021 - 01/2010)
6.	Damania, Apeksha: 5 articles (01/2018 - 12/2015)
7.	Colombani, Thibault: 4 articles (01/2022 - 01/2019)
8.	Sahiner, Nurettin: 4 articles (08/2021 - 01/2017)
9.	Shiekh, Parvaiz A: 4 articles (10/2020 - 06/2018)
10.	Welzel, Petra B: 4 articles (10/2020 - 01/2017)

Related Diseases

1.	Wounds and Injuries (Trauma) 11/07/2020 - "The obtained cryogel provides the required hydrophilicity beneficial for wound treatment. " 06/01/2022 - "Based on the in vivo study of the multifunctional mixed cryogels, it promotes fibroblasts' adhesion and proliferation and significantly improves cell proliferation and tissue remodelling in wound beds. " 01/01/2021 - "Further studies require to determine the effects of combined use of platelet cryogel plus MSCs on other types of wound and evaluate mechanisms involved in wound healing like collagenesis and inflammatory factors." 01/01/2021 - "The development of novel biocompatible and cost effective cryogel membrane which shows enhanced antimicrobial properties in order to use for several approaches such as wound dressing, scaffold or food packaging was aimed in this study. " 06/22/2016 - "In this study, the potential of cryogel bilayer wound dressing and skin regenerating graft for the treatment of surgically created full thickness wounds was evaluated. "
2.	Infections 10/14/2022 - "The first attempts to apply cryogels for the 3D co-culturing of bacteria and human cells have been undertaken toward the development of new models of host-pathogen interactions and bioimplant-associated infections. " 01/01/2018 - "A preliminary in vitro evaluation of the bioactive potential of cryogel scaffolds incorporated with Manuka honey for the treatment of chronic bone infections." 01/01/2023 - "Therefore, SA/PDA cryogels with simple preparation process, low cost, and good biocompatibility would be applied in the variety of great clinical applications in bleeding control, anti-infection and wound healing, etc." 06/01/2022 - "Cryogels has excellent tissue adhesion, blood cell coagulation and hemostasis, anti-infection, and cell recruitment functions. " 05/18/2023 - "Thus, the new cryogels with MET may be promising dosage forms for the treatment of vaginal infections."
3.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "Finally, we investigated the interactions between the HA-based cryogels and CD44-positive breast tumor cells, individually or as MCTS. " 08/27/2018 - "Three-Dimensional In Vitro Hydro- and Cryogel-Based Cell-Culture Models for the Study of Breast-Cancer Metastasis to Bone." 01/01/2023 - "In vivo tumor treatment experiments indicated that chemoimmunotherapy using the SH cryogel platform could inhibit the growth of breast cancer tumors to the greatest extent. " 01/01/2022 - "Next, biomimetic cryogel scaffolds fabricated from hyaluronic acid (HA) were utilized as a platform to reconstruct breast tumor microtissues with aspects of the complex tumor microenvironment in three dimensions. " 01/01/2022 - "Engineering hyaluronic acid-based cryogels for CD44-mediated breast tumor reconstruction."
4.	Neoplasms (Cancer) 01/01/2023 - "Adoptive T cell transfer and host antigen-presenting cell recruitment with cryogel scaffolds promotes long-term protection against solid tumors." 01/01/2023 - "To avoid immune reactions by the materials of delivery systems, herein, a new kind of zwitterionic cryogels (SH cryogels) with extremely low immunogenicity was prepared for chemoimmunotherapy of cancer. " 01/01/2022 - "RGD-free HA-based cryogels represent an effective starting point for designing tumor models for preclinical research, therapeutic drug screening, and early cancer diagnosis." 01/01/2022 - "Moreover, DC trafficking and activation state were not impacted when cryogels were injected near a tumor. " 06/28/2021 - "Selected representative biomedical applications demonstrate how cryogel-based materials have been used in drug delivery, tissue engineering, regenerative medicine, cancer research, and sensing."
5.	Inflammation (Inflammations) 08/15/2023 - "These bioactive cryogels also stimulated improved bone regeneration in vivo through modulation of inflammation, angiogenesis and osteogenesis responses, suggesting an effective strategy to develop bioactive matrices with complex anisotropic structures beneficial to tissue regeneration." 05/04/2022 - "In comparison, cryogels of large pore size or high porosity can induce M2 polarization in vivo, resulting in the anti-inflammation effects. " 04/20/2022 - "An in vivo evaluation of a rat liver hemostasis model and rat skin defect model revealed that the cryogel in fast hemostasis has great potential and superior wound-healing abilities, decreases immune inflammation, and promotes the regeneration of angiogenesis and hair follicles. " 12/04/2021 - "Besides, the cryogels showed well cytocompatibility in the in vitro experiments and exhibited upregulated expression levels of pro-inflammation-related genes (Tnfa and Il1b) with the increase of pore size. " 11/01/2023 - "Delivery from subcutaneously injected HA cryogels was assessed and a formulation which enhanced the immune response while minimizing the inflammation associated with the foreign body response was identified, termed CpG-OVA-HAC2. "

Related Drugs and Biologics

1.	Gelatin
2.	Chitosan
3.	Antioxidants
4.	Doxorubicin (Adriamycin)
5.	Anti-Infective Agents (Microbicides)
6.	Carbamates
7.	Hydrogels
8.	Tissue Adhesives (Tissue Adhesive)
9.	Glutathione (Reduced Glutathione)
10.	Dihydroxyphenylalanine (Dopa)

Related Therapies and Procedures

1.	Bioreactors (Bioreactor)
2.	Injections
3.	Artificial Skin
4.	Operative Surgical Procedures
5.	Therapeutics