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Aldosterone Synthase (CYP11B2)

A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE.
Also Known As:
CYP11B2; Aldosterone Synthase Cytochrome P-450; Aldosynthase; CYP 11B2; Cyctochrome P-450 c11AS; Cytochrome P-450c11AS; Cytochrome P450 11B2; Cytochrome P450Aldo; P450c11AS; Cytochrome P 450 CYP11B2; Cytochrome P 450c11AS; Steroid 18 Hydroxylase; Cytochrome P-450 CYP11B2; Steroid 18-Hydroxylase
Networked: 459 relevant articles (8 outcomes, 86 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hartmann, Rolf W: 15 articles (08/2015 - 06/2002)
2. Rainey, William E: 10 articles (08/2015 - 08/2004)
3. Jeng, Arco Y: 9 articles (06/2015 - 07/2008)
4. Gomez-Sanchez, Celso E: 8 articles (12/2015 - 07/2002)
5. Veglio, Franco: 8 articles (08/2015 - 07/2002)
6. Mulatero, Paolo: 8 articles (08/2015 - 07/2002)
7. Davies, Eleanor: 8 articles (09/2013 - 09/2002)
8. Fraser, Robert: 8 articles (09/2013 - 09/2002)
9. Zhou, Tian-Biao: 7 articles (12/2015 - 09/2015)
10. Sasano, Hironobu: 7 articles (08/2014 - 08/2004)

Related Diseases

1. Fibrosis (Cirrhosis)
2. Ventricular Remodeling
3. Cardiovascular Diseases (Cardiovascular Disease)
4. Diabetic Nephropathies (Diabetic Nephropathy)
5. Dilated Cardiomyopathy (Cardiomyopathy, Congestive)

Related Drugs and Biologics

1. Aldosterone Synthase (CYP11B2)
2. Aldosterone
3. Aromatase (CYP19)
4. Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)
5. Collagen
6. torsemide (torasemide)
7. Metyrapone
8. Furosemide (Lasix)
9. Estrogens (Estrogen)
10. Mineralocorticoid Receptors (Mineralocorticoid Receptor)

Related Therapies and Procedures

1. Adrenalectomy
2. Subcutaneous Infusions
3. Renal Dialysis (Hemodialysis)
4. Catheters
5. Drug Therapy (Chemotherapy)