Abstract | AIM: METHODS: 197 type 2 diabetic patients and 71 healthy controls were enrolled. The study subjects were divided into four groups: healthy controls with normoalbuminuria (n = 71), normoalbuminuric diabetic group (n = 71), microalbuminuric diabetic group (n = 51) and overt proteinuria group (n = 51). Polymorphism of aldosterone synthase gene was determined using standard PCR technique. RESULTS: Higher frequency of TT genotype and T allele in steroidogenic factor-1 (SF-1) binding site and wild type (WT) in intronic conversion (IC) in CYP11B2 was observed in diabetic patients than controls. However, there was no significant difference in SF-1 and IC genotype among diabetic patients according to the state of diabetic nephropathy. Subgroup analysis based on SF-1 polymorphism demonstrated that TT genotype is associated with higher systolic and diastolic blood pressure and higher plasma aldosterone level. In addition, WT in IC genotype showed a significantly higher urinary albumin excretion rate. Plasma aldosterone level was significantly related with systolic blood pressure. CONCLUSION:
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Authors | Gang Jee Ko, Young Sun Kang, Mi Hwa Lee, Hye Kyoung Song, Hyoung Kyu Kim, Dae Ryong Cha |
Journal | Nephrology (Carlton, Vic.)
(Nephrology (Carlton))
Vol. 13
Issue 6
Pg. 492-9
(Dec 2008)
ISSN: 1440-1797 [Electronic] Australia |
PMID | 18771471
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aldosterone
- Cytochrome P-450 CYP11B2
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Topics |
- Adult
- Aged
- Aldosterone
(blood)
- Cytochrome P-450 CYP11B2
(genetics)
- Diabetes Mellitus, Type 2
(complications, genetics)
- Diabetic Nephropathies
(etiology, genetics)
- Female
- Gene Frequency
- Genotype
- Humans
- Hypertension
(etiology, genetics)
- Male
- Middle Aged
- Polymorphism, Genetic
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