Tyrosine Phenol-Lyase

An enzyme that catalyzes the cleavage of tyrosine to phenol, pyruvate, and ammonia. It is a pyridoxal phosphate protein. The enzyme also forms pyruvate from D-tyrosine, L-cysteine, S-methyl-L-cysteine, L-serine, and D-serine, although at a slower rate. EC 4.1.99.2.

Also Known As:

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Abe, Takaaki: 1 article (01/2019)
2.	Akiyama, Yasutoshi: 1 article (01/2019)
3.	Akiyama, Yukako: 1 article (01/2019)
4.	Asaji, Kei: 1 article (01/2019)
5.	Breeggemann, Matthew C: 1 article (01/2019)
6.	Fukuda, Noriko N: 1 article (01/2019)
7.	Fukuda, Shinji: 1 article (01/2019)
8.	Heymann, Jurgen: 1 article (01/2019)
9.	Ho, Hsin-Jung: 1 article (01/2019)
10.	Hozawa, Atsushi: 1 article (01/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Along with significant progress in identification of metabolic vulnerabilities of cancer cells, new amino acid-cleaving enzymes appear as promising agents for cancer treatment: lysine oxidase, tyrosine phenol-lyase, cysteinase, and phenylalanine ammonia-lyase. "
2.	Melanoma (Melanoma, Malignant) 01/01/1976 - "Tyrosine phenol-lyase from Erwinia herbicola was purified with the goal of assessing its effect on growth of malignant melanoma. " 01/01/1976 - "Some biological properties and an in vivo evaluation of tyrosine phenol-lyase on growth of B-16 melanoma."
3.	Albuminuria 01/01/2019 - "Inhibition of tyrosine phenol-lyase, a bacterial enzyme responsible for the synthesis of phenol from dietary tyrosine before it is metabolized into phenyl sulfate in the liver, reduces albuminuria in diabetic mice. "

Related Drugs and Biologics

1.	Enzymes
2.	Phenol (Carbolic Acid)
3.	Tyrosine (L-Tyrosine)
4.	Sulfates (Sulfates, Inorganic)
5.	Phenylalanine Ammonia-Lyase
6.	Oxidoreductases (Dehydrogenase)
7.	Lysine (L-Lysine)
8.	Amino Acids