Cytidine Monophosphate N-Acetylneuraminic Acid

A nucleoside monophosphate sugar which donates N-acetylneuraminic acid to the terminal sugar of a ganglioside or glycoprotein.
Also Known As:
CMP-Sialic Acid; Cytidine Monophosphate N Acetylneuraminic Acid; Acetylneuraminic Acid, CMP; Acid, CMP Acetylneuraminic; Acid, CMP-Sialic; CMP Sialic Acid; CMP Acetylneuraminic Acid; CMP-NANA; D-glycero-beta-D-galacto-2-Nonulopyranosonic acid, 5-(acetylamino)-3,5-dideoxy-, 2-(hydrogen 5'-cytidylate)
Networked: 24 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Gerardy-Schahn, Rita: 2 articles (08/2013 - 09/2005)
2. Bork, Kaya: 2 articles (09/2007 - 09/2005)
3. Horstkorte, Rüdiger: 2 articles (09/2007 - 09/2005)
4. Reutter, Werner: 2 articles (09/2007 - 09/2005)
5. Ashikov, Angel: 1 article (08/2013)
6. van den Heuvel, B: 1 article (08/2013)
7. Robben, Joris H: 1 article (08/2013)
8. Wevers, Ron A: 1 article (08/2013)
9. Lefeber, Dirk J: 1 article (08/2013)
10. de Brouwer, Arjan P M: 1 article (08/2013)

Related Diseases

1. Infection
08/15/1994 - "As a result of a series of elegant and in depth studies, Smith and Parsons and their colleagues showed that growth in CMP-NANA confers on the gonococcus a high degree of phenotypic (readily reversible) serum resistance and that CMP-NANA is available in vivo at sites of gonococcal infection and disease; gonococci become covalently coated with sialic acid and they become serum resistant (reviewed in refs. "
10/01/1980 - "Endogenous replacement of receptors by the cell occurred slowly but supported maximal levels of infection within 6 hr. In contrast, sialylation during a 20-min incubation with CMP-sialic acid and beta-galactoside alpha 2,3-sialytransferase restored full susceptibility to infection. "
09/05/2006 - "Characterization of this new baculovirus vector showed that it induced high levels of intracellular CMP-sialic acid and sialylation of the recombinant N-glycoprotein upon infection of SfSWT-1 cells cultured in serum-free medium supplemented with N-acetylmannosamine. "
09/05/2006 - "To eliminate this requirement and extend the utility of SfSWT-1 cells, we have isolated a new baculovirus vector, AcSWT-7B, designed to express two mammalian enzymes that can convert N-acetylmannosamine to CMP-sialic acid during the early phase of infection. "
09/01/1985 - "Cells were treated with sialidase to remove sialic acid and render them resistant to infection and were then incubated with sialyltransferase and CMP-sialic acid to restore sialic acid in the SA alpha 2,6Gal or SA alpha 2,3Gal linkages. "
2. Sialic Acid Storage Disease (Salla Disease)
3. Colorectal Neoplasms (Colorectal Cancer)
4. Neoplasms (Cancer)
5. Leukemia

Related Drugs and Biologics

1. Lactic Acid
2. Nitrite Reductases (Nitrite Reductase)
3. Lipoproteins (Lipoprotein)
4. Heme (Haem)
5. Electron Transport Complex IV (Cytochrome c Oxidase)
6. N-Acetylneuraminic Acid (Sialic Acid)
7. Uridine Diphosphate (UDP)
8. Glycoproteins (Glycoprotein)
9. Enzymes
10. Cytidine