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Electron Transport Complex IV (Cytochrome c Oxidase)

A multisubunit enzyme complex containing CYTOCHROME A GROUP; CYTOCHROME A3; two copper atoms; and 13 different protein subunits. It is the terminal oxidase complex of the RESPIRATORY CHAIN and collects electrons that are transferred from the reduced CYTOCHROME C GROUP and donates them to molecular OXYGEN, which is then reduced to water. The redox reaction is simultaneously coupled to the transport of PROTONS across the inner mitochondrial membrane.
Also Known As:
Cytochrome c Oxidase; Oxidase, Cytochrome; Cytochrome-c Oxidase (Complex IV); Cytochrome Oxidase; Cytochrome Oxidase Subunit III; Cytochrome a,a3; Cytochrome c Oxidase Subunit VIa; Cytochrome-c Oxidase Subunit III; Cytochrome-c Oxidase Subunit IV; Ferrocytochrome c Oxygen Oxidoreductase; Heme aa3 Cytochrome Oxidase; Pre-CTOX p25; Signal Peptide p25-Subunit IV Cytochrome Oxidase; Subunit III, Cytochrome Oxidase; p25 Presequence Peptide-Cytochrome Oxidase; Cytochrome c Oxidase Subunit III; Cytochrome c Oxidase Subunit IV; Oxidase, Cytochrome-c; Signal Peptide p25 Subunit IV Cytochrome Oxidase; p25 Presequence Peptide Cytochrome Oxidase; Cytochrome aa3; Cytochrome-c Oxidase; Ferricytochrome-c:oxygen oxidoreductase
Networked: 2202 relevant articles (38 outcomes, 200 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Zeviani, Massimo: 20 articles (01/2021 - 08/2002)
2. Taylor, Robert W: 19 articles (01/2020 - 02/2004)
3. Tachtsidis, Ilias: 15 articles (10/2019 - 03/2007)
4. Avadhani, Narayan G: 12 articles (08/2020 - 03/2003)
5. Oldfors, Anders: 11 articles (01/2021 - 02/2005)
6. DiMauro, Salvatore: 10 articles (06/2017 - 02/2003)
7. Hüttemann, Maik: 9 articles (01/2021 - 03/2012)
8. Turnbull, Douglass M: 9 articles (02/2013 - 11/2002)
9. Blakely, Emma L: 8 articles (06/2019 - 02/2008)
10. Saada, Ann: 8 articles (01/2019 - 09/2008)

Related Diseases

1. Hypoxia (Hypoxemia)
2. Mitochondrial Diseases (Mitochondrial Disease)
3. Muscular Diseases (Myopathy)
4. Insulin Resistance
5. Polymyositis

Related Drugs and Biologics

1. Adenosine Triphosphate (ATP)
2. Zidovudine (Retrovir)
3. Histocompatibility Antigens Class I
4. Enzymes
5. NADH Dehydrogenase
6. Hemoglobins (Hemoglobin)
7. Oxygen (Dioxygen)
8. NAD (NADH)
9. Glutathione (Reduced Glutathione)
10. Electron Transport Complex I (NADH-CoQ Reductase)

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1. Therapeutics
2. Low-Level Light Therapy (LLLT)
3. Oral Administration
4. Lenses
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