Roundabout Proteins

A family of single-pass transmembrane receptors that act as the cognate receptors for the secreted guidance factor Slit emanating from central nervous system midlines.

Also Known As:

Robo Proteins; Robo-1 Protein; Robo1 Protein; Roundabout 1 Protein

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ha, U-Syn: 1 article (10/2021)
2.	Hong, Sung-Hoo: 1 article (10/2021)
3.	Hur, Kyung Jae: 1 article (10/2021)
4.	Kim, Sang Hoon: 1 article (10/2021)
5.	Kim, Tae-Jung: 1 article (10/2021)
6.	Lee, Ji Youl: 1 article (10/2021)
7.	Shin, Dongho: 1 article (10/2021)
8.	Martinelli, Paola: 1 article (01/2019)
9.	Real, Francisco X: 1 article (01/2019)
10.	Guo, Yaman: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2019 - "SLIT/ROBO proteins thus link development and cancer, but appear to have distinct functions in health and disease." 01/01/2018 - "Moreover, the interaction between USP33 and Robo1 protein was identified, and knockdown of Robo1 enhancing the oncogenic effect upon USP33-knockdown, suggesting that USP33 may inhibit tumor progression through Robo1 signaling. " 01/01/2008 - "One such pathway uses Slit-Roundabout proteins that are implicated in the development of cancers and tumour angiogenesis. " 09/15/2004 - "Substantial reduction of Dutt1/Robo1 protein expression in tumors is observed by Western blotting and immunohistochemistry. " 06/01/2006 - "It has recently been shown that Robo proteins are also associated with tumor angiogenesis with Slit2 acting as the corresponding ligand. "
2.	Cholangiocarcinoma 01/01/2023 - "Herein, we examined the expression patterns of SLIT and ROBO proteins in normal adult livers and two types of liver cancers: hepatocellular carcinoma and cholangiocarcinoma. "
3.	Colorectal Neoplasms (Colorectal Cancer) 06/01/2006 - "Therefore, the Robo proteins provide potential target structures for the anti-tumorigenic and anti-angiogenic therapy of colorectal carcinoma."
4.	Prostatic Neoplasms (Prostate Cancer) 10/01/2021 - "ROBO1 protein expression is independently associated with biochemical recurrence in prostate cancer patients who underwent radical prostatectomy in Asian patients."
5.	Liver Neoplasms (Liver Cancer) 01/01/2023 - "Herein, we examined the expression patterns of SLIT and ROBO proteins in normal adult livers and two types of liver cancers: hepatocellular carcinoma and cholangiocarcinoma. "

Related Drugs and Biologics

1.	Ligands

Related Therapies and Procedures

1.	Therapeutics
2.	Prostatectomy (Retropubic Prostatectomy)