Matrines

01/01/2016 - "The in vitro growth inhibitory assays showed that most of the prepared compounds exhibited improved anti-proliferative activities towards cancer cells with IC50 17-109 times lower than that of matrine. "
08/01/2017 - "Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. "
12/01/2023 - "This study aimed to investigate the anti-tumor effect of matrine on the proliferation and apoptosis of TNBC cells based on HN1 regulation in vitro and in vivo. "
01/01/2022 - "This study provides scientific basis for the development of matrine derivatives to c-Myc-driven cancers."
10/12/2021 - "The purpose of this study was to find the molecular target of matrine to inhibit the proliferation of cancer cells and explore its mechanism of action. "

01/01/2011 - "Matrine suppresses production of IL-23/IL-17 and ameliorates experimental autoimmune encephalomyelitis."
11/01/2023 - "Expression of concern: Matrine downregulates IL-33/ST2 expression in the central nervous system of rats with experimental autoimmune encephalomyelitis Immunology Letters, Volume 178, Pages 97 - 104, 1 October 2016."
02/01/2023 - "Corrigendum to "Upregulation of immunomodulatory molecules by matrine treatment in experimental autoimmune Encephalomyelitis." [Experimental and Molecular Pathology. "
07/01/2022 - "Correction to: Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis."
12/01/2017 - "Matrine Treatment Blocks NogoA-Induced Neural Inhibitory Signaling Pathway in Ongoing Experimental Autoimmune Encephalomyelitis."

12/01/2014 - "The rats with heart failure exhibited a significant reduction in ejection fraction and fractional shortening, as well as an increase in the left ventricular end systolic dimension, and matrine attenuated this decline in heart function. "
01/01/2016 - "In this study, the effect of sophoridine on heart failure was investigated using Sprague-Dawley (SD) rat model of chronic heart failure. "
12/01/2014 - "The purpose of the present study was to investigate whether matrine has a protective effect on heart failure in rats. "
01/01/2016 - "Our results suggest that sophoridine could improve heart failure by ameliorating cardiac Ca(2+) induced Ca(2+) transients, and that this amelioration is associated with upregulation of DHPR."
01/01/2016 - "However, the effect of sophoridine on heart failure has not been known yet. "

09/01/2015 - "In this study, we aimed to determine whether these protective effects of matrine can be applied to cerebral ischemia. "
08/01/2020 - "To explore the effect of matrine intervention of different concentrations on JAK2/STAT3 signaling pathway and brain protection in rats with cerebral ischemia-reperfusion. "
08/01/2020 - "Effect of matrine on JAK2/STAT3 signaling pathway and brain protection in rats with cerebral ischemia-reperfusion."
05/15/2012 - "Direct protection of neurons and astrocytes by matrine via inhibition of the NF-κB signaling pathway contributes to neuroprotection against focal cerebral ischemia."
08/01/2020 - "In the model group, the middle cerebral artery was occluded with suture method to establish cerebral ischemia-reperfusion model rats, which were subdivided into cerebral ischemia-reperfusion group, and 5, 10 and 20 mg/kg matrine groups, with 20 rats in each group. "

01/01/2017 - "In this study, we evaluated the anticancer efficacy of a novel derivative of matrine, (6aS, 10S, 11aR, 11bR, 11cS)-10- methylamino-dodecahydro- 3a,7a-diazabenzo (de) (MASM), against human hepatocellular carcinoma (HCC) cells and their corresponding sphere cells in vitro and in vivo. "
10/01/2023 - "Previous studies have shown the anticancer effect of Matrine on hepatocellular carcinoma (HCC); however, the underlying mechanism is still indistinct. "
10/01/2019 - "The aim of the present study was to determine the chemopreventive effect of matrine on the development of primary hepatocellular carcinoma (HCC) and its possible association with the suppression of the Notch signaling pathway. "
07/01/2018 - "Therefore, the aims of the present study were to evaluate the effects of matrine on hepatoma and to determine the associated mechanism(s) involved. "
02/01/2018 - "In the present study, a preliminary study was performed on the mechanisms of matrine on hepatocellular carcinoma (HCC) stem-like cells. "