Angiopoietin-Like Protein 8

A nutritionally-regulated factor found in the LIVER. It plays a role in lipid metabolism and VLDL secretion in the liver. It was originally called betatrophin due to its suspected role as a peptide hormone that stimulates beta cell proliferation.

Also Known As:

Networked: 188 relevant articles (8 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Abu-Farha, Mohamed: 7 articles (03/2018 - 06/2015)
2.	Abubaker, Jehad: 7 articles (03/2018 - 06/2015)
3.	Yuan, Guoyue: 6 articles (06/2019 - 10/2014)
4.	Cherian, Preethi: 6 articles (03/2018 - 06/2015)
5.	Frühbeck, Gema: 5 articles (11/2021 - 10/2014)
6.	Gómez-Ambrosi, Javier: 5 articles (11/2021 - 10/2014)
7.	Li, Ling: 5 articles (10/2021 - 01/2016)
8.	Catalán, Victoria: 4 articles (11/2021 - 10/2014)
9.	Rodríguez, Amaia: 4 articles (11/2021 - 10/2014)
10.	Silva, Camilo: 4 articles (11/2021 - 10/2014)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 09/29/2020 - "This study tested the association between serum levels of microRNA-486, -146b and -15b and betatrophin in normal and obese children with/without type 2 diabetes mellitus (T2DM). " 10/01/2016 - "The study demonstrated that compared with type 2 diabetes without CVD, those with CVD had remarkably higher levels of angiopoietin-like protein 8 (ANGPTL8). " 09/01/2016 - "Hence, the aim of this study was to investigate circulating betatrophin concentrations in normal and type 2 diabetes mellitus (T2DM) Saudi subjects and its association with various metabolic parameters. " 03/01/2016 - "This study aimed to measure serum betatrophin concentrations in patients with type 2 diabetes (T2DM) and evaluate the association of betatrophin with diabetic retinopthy (DR). " 12/01/2015 - "The purpose of the current study was to examine circulating betatrophin levels in Iranian patients with type 2 diabetes mellitus (T2DM) and in normal controls. "
2.	Insulin Resistance 01/01/2021 - "Our study may provide a new perspective of ANGPTL8/betatrophin in insulin resistance from the metabolic changes. " 11/14/2017 - "Circulating betatrophin is associated with insulin resistance in humans: cross-sectional and interventional studies in vivo and in vitro." 10/01/2017 - "More large-scale studies are needed to determine whether improving insulin resistance concomitantly declines betatrophin levels in different diseases." 10/01/2017 - "The databases of PubMed, EMBASE, and the Cochrane Library (inception to October 26, 2016) were searched without language restrictions for publications that reported studies on associations between betatrophin and insulin resistance in adults. " 02/01/2017 - "This study suggests that betatrophin may potentially serve as an independent predictor for the development of PCOS in at-risk women, especially those with insulin resistance."
3.	Metabolic Diseases (Metabolic Disease) 12/01/2019 - ": Betatrophin levels were shown to correlate with TBA levels, it provides a model for future studies to understand the physiopathology of ICP, a complex metabolic disease. " 01/01/2022 - "Betatrophin may be associated with metabolic diseases. " 02/01/2018 - "Circulating levels of betatrophin are altered in various metabolic diseases, although the results are inconsistent. " 02/01/2018 - "Serum Betatrophin Concentrations and the Risk of Incident Diabetes: A Nested Case-Control Study from Chungju Metabolic Disease Cohort." 11/01/2017 - "ANGPTL8 (betatrophin) role in diabetes and metabolic diseases."
4.	Non-alcoholic Fatty Liver Disease 01/01/2017 - "Serum betatrophin may be helpful for the early diagnosis of NAFLD and improvement of its prognosis." 04/01/2018 - "This study aimed to investigate the relationship between serum betatrophin levels and non-alcoholic fatty liver disease in obese children. " 01/01/2017 - "This study aimed to investigate the association of serum betatrophin with the status and progression of nonalcoholic fatty liver disease (NAFLD). " 04/05/2016 - "Association between betatrophin/ANGPTL8 and non-alcoholic fatty liver disease: animal and human studies." 06/28/2021 - "Betatrophin levels are higher in the early stages of NAFLD and tend to decrease when the disease progresses. "
5.	Hyperglycemia 11/01/2019 - "Recombinant betatrophin (Angptl‑8/lipasin) ameliorates streptozotocin‑induced hyperglycemia and β‑cell destruction in neonatal rats." 01/01/2016 - "We hypothesized that betatrophin levels are increased in the cord blood in offspring exposed to intrauterine hyperglycemia. " 11/01/2019 - "It was found that betatrophin treatment alleviated STZ‑induced hyperglycemia, elevated pancreatic expression levels of Bcl‑2, PDX‑1, plasma insulin levels and the β‑cell proliferation rate on days 4 and 7. " 11/01/2016 - "Obesity is associated with increased betatrophin suppression after an oral glucose load, which is driven by increased hyperglycemia. " 01/01/2016 - "Cord blood betatrophin may function as a potential biomarker of maternal intrauterine hyperglycemia and fetal insulin resistance, which may presage for long-term metabolic impact of GDM on offspring."

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Triglycerides (Triacylglycerol)
3.	Angiopoietin-Like Protein 8
4.	Hormones (Hormone)
5.	Lipids
6.	Estrogens (Estrogen)
7.	Apolipoprotein C-III
8.	Lipoprotein Lipase (Diacylglycerol Lipase)
9.	Lipoproteins (Lipoprotein)
10.	Carbohydrates

Related Therapies and Procedures

1.	Gastric Bypass (Roux-en-Y Gastric Bypass)
2.	Bariatric Surgery
3.	Glycemic Control
4.	Cardiopulmonary Resuscitation (CPR)
5.	Therapeutics