Angiomotins

A class of intracellular signaling proteins that were originally identified as inhibitors of ANGIOSTATIN activity. They play a role in cell signaling pathways such as those involving G-PROTEINS and the HIPPO-SIGNALING PATHWAY.

Also Known As:

Networked: 56 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Holmgren, Lars: 8 articles (01/2016 - 02/2004)
2.	Yang, Jin: 5 articles (01/2021 - 06/2013)
3.	Liu, Peijun: 4 articles (01/2017 - 06/2013)
4.	Shen, Yanwei: 3 articles (01/2021 - 03/2016)
5.	Lv, Meng: 3 articles (01/2017 - 04/2015)
6.	Cavallo, Federica: 3 articles (01/2016 - 06/2006)
7.	Kissil, Joseph L: 3 articles (08/2014 - 04/2011)
8.	Levchenko, Tetyana: 3 articles (03/2008 - 02/2004)
9.	Martín-Vasallo, Pablo: 2 articles (01/2022 - 04/2017)
10.	Morales, Manuel: 2 articles (01/2022 - 04/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "Angiomotin Family Members: Oncogenes or Tumor Suppressors?" 09/03/2013 - "Angiomotin'g YAP into the nucleus for cell proliferation and cancer development." 01/01/2012 - "In contrast, antiangiogenic and dormancy promoting pathways such as EphA5 and Angiomotin were upregulated in DmiR over-expressing tumors. " 12/01/2021 - "Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling." 01/01/2016 - "Angiomotin has a role in angiogenesis, cell proliferation, and invasion in human malignancies, including osteosarcoma. "
2.	Breast Neoplasms (Breast Cancer) 10/01/2015 - "It has been reported that the expression of angiomotin (AMOT) is upregulated in breast cancer. " 04/01/2015 - "Angiomotin promotes breast cancer cell proliferation and invasion." 01/23/2006 - "Breast cancer tissues expressed significantly higher levels of angiomotin transcript, compared with normal mammary tissues (33.1 +/- 11 in normal versus 86.5 +/- 13.7 in tumour tissues, p = 0.003). " 12/09/2019 - "Here, we identified a circular RNA of angiomotin-like 1 (circAMOTL1) as an important player which may be responsible for the adverse resistance against PAX in breast cancer cells. " 01/01/2019 - "Apatinib suppresses breast cancer cells proliferation and invasion via angiomotin inhibition."
3.	Carcinoma (Carcinomatosis) 03/15/2016 - "Angiomotin promotes renal epithelial and carcinoma cell proliferation by retaining the nuclear YAP." 01/01/2020 - "CircAMOTL1 (angiomotin-like1, ID: hsa_circ_0004214), which is located on human chromosome 11:9 4532555-94533477, is involved in the occurrence of breast cancer, etc. However, the intrinsic and concrete molecular mechanism of circAMOTL1 in cervical carcinomas remained thoroughly unclear, which was also the bottleneck of circRNAs studies in cancer. "
4.	Carcinogenesis 11/01/2017 - "Angiomotin (AMOT) promotes angiogenesis and plays a role in neovascularization during tumorigenesis. " 04/12/2011 - "Depletion of Angiomotin in Nf2(-/-) Schwann cells attenuates the Ras-MAPK signaling pathway, impedes cellular proliferation in vitro and tumorigenesis in vivo." 09/03/2013 - "The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis." 12/01/2021 - "Angiomotin-like 1 (AMOTL1) is reportedly a pivotal tumor-associated protein that is strongly associated with the tumorigenesis of multiple malignant tumors. "
5.	Stomach Neoplasms (Stomach Cancer) 03/01/2021 - "To explore the regulatory relationship between Chloride intracellular channel 1 (CLIC1) and Angiomotin (AMOT)-p130, and reveal the role of AMOT-p130 in gastric cancer (GC). " 01/01/2021 - "Growing evidence indicates that Angiomotin (Amot)-p130 plays an important role in types of cancer, including breast cancer and gastric cancer. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Circular RNA
3.	Tankyrases
4.	Phosphotransferases (Kinase)
5.	Neurofibromin 2 (Merlin)
6.	Biomarkers (Surrogate Marker)
7.	Vaccines
8.	Angiomotins
9.	Oxaliplatin (Eloxatin)
10.	Long Noncoding RNA

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics