Vaccine Adjuvants

Substances consisting of different components, e.g. aluminum salts, EMULSIONS such as MF59 and AS03, Toll-like receptor (TLR) agonist or combinations of IMMUNOPOTENTIATORS (QS-21 and MPL in AS01), that helps increase the magnitude of an ADAPTIVE IMMUNE RESPONSE to a VACCINE.

Also Known As:

Networked: 555 relevant articles (55 outcomes, 70 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ishii, Ken J: 10 articles (01/2022 - 04/2004)
2.	Aoshi, Taiki: 7 articles (01/2021 - 01/2010)
3.	Klinman, Dennis M: 7 articles (01/2016 - 06/2002)
4.	Kuroda, Etsushi: 5 articles (01/2022 - 04/2015)
5.	Matsumoto, Misako: 5 articles (12/2018 - 12/2015)
6.	Seya, Tsukasa: 5 articles (12/2018 - 12/2015)
7.	Coban, Cevayir: 4 articles (01/2022 - 01/2010)
8.	Gerdts, Volker: 4 articles (01/2022 - 03/2009)
9.	O'Hagan, Derek T: 4 articles (01/2021 - 10/2007)
10.	Krieg, Arthur M: 4 articles (04/2012 - 10/2008)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2014 - "2'3'-cG(s)A(s)MP is therefore improved over natural 2'3'-cGAMP as a model agonist and has potential as a vaccine adjuvant and cancer therapeutic. " 01/01/2023 - "The development of vaccine adjuvants is of interest for the management of chronic diseases, cancer, and future pandemics. " 11/29/2018 - "There is an unmet clinical need for vaccine adjuvants that induce T cells responses to potentially enhance protection against malignancies and intracellular pathogens, where a humoral response, alone, may not be adequate for protection. " 01/01/2022 - "The therapeutic potentials of treated cancer cell plus different vaccine adjuvants were assessed by in vivo liver tumor model and in vitro mixed lymphocyte reaction studies. " 01/01/2018 - "In the current study, we evaluate the use of apoptosis inhibitor 5 (API5), a damage-associated molecular pattern expressed by many human cancer cells, as a novel DC vaccine adjuvant. "
2.	Infections 12/12/2007 - "These studies may help to guide the formulation of vaccine adjuvants to maintain effectiveness in hosts with altered immunological environment that often result from infections." 03/01/2009 - "This study demonstrates that IFN-beta potentiates DC immunological functions following BCG infection, thus suggesting IFN-beta as a possible candidate as vaccine adjuvant." 01/01/2023 - "Background: Various vaccine adjuvants have been developed to eliminate HBV from patients with chronic HBV infection. " 01/01/2021 - "Mitochondria-dependent synthetic small-molecule vaccine adjuvants for influenza virus infection." 06/16/2020 - "Taken together, our results strongly suggest that EcML might be a promising vaccine adjuvant for preventing influenza virus infection."
3.	Communicable Diseases (Infectious Diseases) 07/13/2022 - "This article highlights recent advances in vaccine adjuvant development and provides detailed data from pre-clinical and clinical studies specific to infectious diseases. " 01/01/2019 - "In our study we investigated a new strategy to strengthen vaccine adjuvant in order to increase immunity against infectious diseases. " 08/04/2023 - "L-pampo™, a proprietary vaccine adjuvant of TLR2 and TLR3 agonists, promotes strong humoral and cellular immune responses against infectious diseases. " 07/13/2022 - "Advances in Infectious Disease Vaccine Adjuvants." 03/01/2022 - "Finally, we discuss future approaches for the development of iNKT cell agonists used as vaccine adjuvants against infectious diseases."
4.	Human Influenza (Influenza) 01/01/2017 - "In 2009, the global outbreak of an influenza pandemic emphasized the need for an effective vaccine adjuvant. " 01/01/2016 - "TLR vaccine adjuvants: closing the stable door before novel influenza strains bolt?" 03/01/2013 - "[Introduction to novel vaccine adjuvants and their role in influenza vaccination]." 02/01/2018 - "These results suggest that MENK, given via intranasal administration, could provide a novel drug with a new mode of action as a nonspecific anti-influenza agent or vaccine adjuvant." 01/01/2022 - "Importantly, sustained protection against a lethal influenza infection was detected a year after a single dose of the vaccine-adjuvant."
5.	Virus Diseases (Viral Diseases) 01/01/2023 - "The immunomodulatory and vaccine adjuvant properties of LNT help in mitigating viral infections too. " 01/01/2021 - "Design and application of nanoparticles as vaccine adjuvants against human corona virus infection." 06/01/2010 - "These results support the continued development of anti-GITR for such indications as haematological and solid tumours, chronic viral infections, and as a vaccine adjuvant." 01/01/2010 - "Synthetic dsRNA analogues have been tested as vaccine adjuvant against viral infections in animal models. " 11/01/2020 - "Both preclinical and clinical studies have shown the downstream inflammatory response from TLR7 and TLR8 agonism results in preliminary efficacy for the treatment of cancer, viral infections, and for use as a vaccine adjuvant. "

Related Drugs and Biologics

1.	Vaccines
2.	Proteins (Proteins, Gene)
3.	CPG-oligonucleotide
4.	Antigens
5.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
6.	Chitosan
7.	bis(3',5')-cyclic diguanylic acid
8.	MF59 oil emulsion
9.	Ligands
10.	Oligodeoxyribonucleotides

Related Therapies and Procedures

1.	Immunotherapy
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Subcutaneous Injections
5.	Immunomodulation