Uveal Effusion Syndrome

Rare disease characterized by suprachoroidal fluid accumulation between the CHOROID and the SCLERA, annular detachment of the CHOROID, often with secondary RETINAL DETACHMENT; OPTIC DISK EDEMA, and minimal signs of UVEITIS and INTRAOCULAR PRESSURE changes.

Also Known As:

Networked: 52 relevant articles (4 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Viral Encephalitis
2.	Hyperopia (Hypermetropia)
3.	Choroidal Effusions
4.	Retinal Detachment (Retinal Detachments)
5.	Angle-Closure Glaucoma (Glaucoma, Angle Closure)

Experts

1.	Jackson, Timothy L: 2 articles (09/2021 - 01/2012)
2.	Jung, Sascha Mathias: 1 article (04/2022)
3.	Todorova, Margarita G: 1 article (04/2022)
4.	Türksever, Cengiz: 1 article (04/2022)
5.	Valmaggia, Christophe: 1 article (04/2022)
6.	Kim, Min: 1 article (01/2022)
7.	Kim, Tae Young: 1 article (01/2022)
8.	Lee, Dong Hyun: 1 article (01/2022)
9.	Lee, Sung Chul: 1 article (01/2022)
10.	Baillif, S: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Uveal Effusion Syndrome:

1.	SteroidsIBA 01/02/2022 - "Uveal effusion syndrome can develop in association with viral encephalitis and be treated successfully with oral and topical steroids; we suggest that medical treatment should be attempted prior to surgery. " 12/01/2017 - "We report one case of a 73-year-old woman with posterior uveal effusion syndrome who developed bilateral chorioretinal folds, treated as uveitis, who did not resolve on oral steroids. " 12/01/1996 - "Efficacy in patients suffering from central retinal vein occlusion and uveal effusion syndrome was proven, even when the patients were resistant to previous haemodilution or steroid therapy. " 12/01/1996 - "We also treated patients with uveal effusion syndrome (n = 3) and central retinal vein occlusion (n = 4) resistant to haemodilution or steroid therapy. " 01/01/1997 - "The patient did not respond well to systemic steroids given in high doses and during slow tapering at the dosage of 30 mg prednisone once per day the symptom of uveal effusion syndrome occurred. "
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/19/2021 - "Using an anti-vascular endothelial growth factor agent alone may be a potentially effective and safe method for managing some types of uveal effusion syndrome, such as in nanophthalmos. " 10/19/2021 - "To the best of our knowledge, no previous report has described a severe uveal effusion syndrome patient with nanophthalmos treated by using an anti-vascular endothelial growth factor agent alone. " 10/19/2021 - "Rapid resolution of severe exudation in uveal effusion syndrome with anti-vascular endothelial growth factor alone in a case of bilateral nanophthalmos: a case report." 08/01/2019 - "To report a case series of three patients with intractable uveal effusion syndrome (UES), treated with partial thickness sclerectomy and intravitreal anti-VEGF therapy. " 08/01/2019 - "Partial thickness sclerectomy and intravitreal anti-VEGF therapy for intractable uveal effusion syndrome."
3.	Adrenal Cortex Hormones (Corticosteroids)IBA 11/01/2017 - "The purpose of the study was to investigate the corticosteroids for uveal effusion syndrome (UES). " 11/01/2017 - "Uveal effusion syndrome in 104 eyes: Response to corticosteroids - The 2017 Axel C. " 01/01/1999 - "Uveal effusion syndrome that is refractory to medical treatment (high-dose systemic corticosteroids) can be managed effectively by pars plana full-thickness unsutured sclerotomy without sclerectomy." 11/28/2023 - "She had been previously diagnosed with idiopathic uveal effusion syndrome and treated with systemic corticosteroid therapy with no response, and was referred to us for scleral window surgery. "
4.	Retinaldehyde (Retinal)IBA 04/01/2022 - "Posterior segment changes included elevated papillomacular retinal fold, uveal effusion syndrome, crowded optic discs, and hypopigmented fundus. " 05/01/2008 - "Six patients (six eyes) with uveal effusion syndrome(UE) underwent vitrectomy followed by internal drainage of subretinal fluid, fluid-gas exchange, and pan-retinal photocoagulation. " 01/01/1999 - "In five eyes of four patients with retinal and choroidal detachment and uveal effusion syndrome due to nanophthalmos, we performed pars plana full-thickness unsutured sclerotomies without sclerectomy. " 01/01/1999 - "To report visual and anatomic outcomes after modified scleral surgery in patients with uveal effusion syndrome with retinal and choroidal detachment. " 03/01/2002 - "Posterior segment changes included bilateral elevated papillomacular retinal fold (13 patients, 72.2%); fine retinal folds (6 patients, 33.3%); chorioretinal folds (11 patients, 61.1%); uveal effusion syndrome (3 patients, 16.7%); pigmentary retinopathy (4 patients, 22.2%), including retinitis punctata albescens in 1 patient; absence or marked reduction of the capillary-free zone (18 patients, 100%); crowded optic discs (18 patients, 100%); and sclerochoroidal thickening on ultrasonography (18 patients, 100%). "
5.	Mitomycin (Mitomycin-C)FDA LinkGeneric 07/01/2009 - "Scleral punch method with topical mitomycin C for safe revision of failed deep sclerectomy in nanophthalmic uveal effusion syndrome." 04/01/1997 - "Topical mitomycin-C may be a useful adjunct in the surgical management of uveal effusion syndrome." 07/01/2021 - "We propose that topical mitomycin-C may be considered as a potential therapeutic adjunct in the treatment of refractory idiopathic uveal effusion syndrome before further sclerostomy procedures are attempted in additional quadrants of the eye." 07/01/2021 - "Successful use of topical mitomycin-C in sclerostomy revision has not previously been reported in idiopathic (non-nanophthalmic) uveal effusion syndrome. " 07/01/2021 - "To describe the use of topical mitomycin-C in sclerostomy revision for recalcitrant idiopathic uveal effusion syndrome. "
6.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 09/01/2002 - "The indocyanine green findings in idiopathic uveal effusion syndrome." 03/02/2021 - "Multimodal imaging showed increased choroidal thickness, choroidal congestion on indocyanine green angiography and peripheral choroidal detachment with normal sclera thickness in our patient, thus pointing towards a diagnosis of uveal effusion syndrome type 3." 09/01/2002 - "We report two cases clinically diagnosed as idiopathic uveal effusion syndrome, where indocyanine green angiogram suggest non-specific choroidal inflammation as the underlying cause. "
7.	ArgonIBA 10/01/1999 - "We report a case of nanophthalmic uveal effusion syndrome (NUES) with total exudative retinal detachment (RD) after prophylactic argon laser (AL) treatment. " 02/01/1990 - "[Uveal effusion syndrome after argon laser treatment in a case of Sturge Weber Krabbe syndrome]."
8.	Fluorescein (Funduscein)FDA LinkGeneric 03/01/2008 - "Fluorescein angioraphy revealed a leopard spots pattern similar to uveal effusion syndrome. "
9.	Triamcinolone (Aristocort)FDA Link 06/01/2008 - "[Intravitreal triamcinolone and bevacizumab injections for alternative treatment of nanophthalmic uveal effusion syndrome]."
10.	Proteins (Proteins, Gene)FDA Link 01/01/1988 - "The uveal effusion syndrome associates bullous no rhegmatognous retinal detachment with shifting subretinal fluid, choroidal detachment and elevated spinal fluid protein. "

Therapies and Procedures

1.	Vitrectomy 05/01/2008 - "To evaluate the efficacy of pars plana vitrectomy for uveal effusion syndrome retrospectively. " 01/29/2021 - "Comparing the Results of Vitrectomy and Sclerectomy in a Patient with Nanophthalmic Uveal Effusion Syndrome." 02/01/1997 - "A 73-year-old man with idiopathic uveal effusion syndrome and total retinal detachment in the right eye underwent quadrantic partial-thickness sclerectomies in conjunction with pars plana vitrectomy, internal drainage of subretinal fluid, and fluid-gas exchange. " 05/01/2008 - "Six patients (six eyes) with uveal effusion syndrome(UE) underwent vitrectomy followed by internal drainage of subretinal fluid, fluid-gas exchange, and pan-retinal photocoagulation. "
2.	Laser In Situ Keratomileusis (LASIK) 04/01/2004 - "To describe the first reported cases of uveal effusion syndrome following laser in situ keratomileusis (LASIK). " 04/01/2004 - "Both cases showed gradual improvement in vision over several weeks, returning to best-corrected visual acuity of 6/6. Uveal effusion syndrome is a previously unreported complication that may occur following LASIK for hypermetropia."
3.	Sclerostomy 01/01/2022 - "In this study, we aimed to investigate clinical characteristics and histopathology and evaluate surgical outcomes of quadrantic lamellar-sclerectomy with sclerostomy for uveal effusion syndrome (UES). " 07/01/2021 - "We propose that topical mitomycin-C may be considered as a potential therapeutic adjunct in the treatment of refractory idiopathic uveal effusion syndrome before further sclerostomy procedures are attempted in additional quadrants of the eye." 07/01/2021 - "Successful use of topical mitomycin-C in sclerostomy revision has not previously been reported in idiopathic (non-nanophthalmic) uveal effusion syndrome. " 07/01/2021 - "To describe the use of topical mitomycin-C in sclerostomy revision for recalcitrant idiopathic uveal effusion syndrome. " 07/01/2021 - "APPLICATION OF ADJUNCTIVE TOPICAL MITOMYCIN-C IN SCLEROSTOMY REVISION FOR REFRACTORY IDIOPATHIC UVEAL EFFUSION SYNDROME."
4.	Therapeutics 02/01/2023 - "Medical Therapy and Scleral Windows for Uveal Effusion Syndrome: A Case Series and Literature Review." 12/01/2017 - "Medical therapy for bilateral uveal effusion syndrome in nanophthalmos." 08/01/2014 - "Medical therapy for uveal effusion syndrome." 07/01/2011 - "Uveal effusion syndrome as a complication of cyclodiode therapy in nanophthalmos glaucoma." 11/28/2023 - "She had been previously diagnosed with idiopathic uveal effusion syndrome and treated with systemic corticosteroid therapy with no response, and was referred to us for scleral window surgery. "
5.	Trabeculectomy (Trabeculoplasty) 05/01/2007 - "[Uveal effusion syndrome in nanophthalmic eye after trabeculectomy]." 08/15/1988 - "Recurrent nanophthalmic uveal effusion syndrome following laser trabeculoplasty." 01/01/2004 - "Posterior uveal effusion syndrome after trabeculectomy in an eye with ocular venous congestion." 01/01/1985 - "[Uveal effusion syndrome following trabeculectomy in a case of Sturge-Weber-Krabbe syndrome]."