WNK Lysine-Deficient Protein Kinase 1

A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Lu, Jeng-Wei: 2 articles (09/2020 - 01/2014)
2.	Cheng, Xin: 1 article (02/2022)
3.	Jiang, Huiyuan: 1 article (02/2022)
4.	Li, Yaoping: 1 article (02/2022)
5.	Li, Yiqun: 1 article (02/2022)
6.	Liang, Yanjie: 1 article (02/2022)
7.	Wang, Yan: 1 article (02/2022)
8.	Chang, Jungshan: 1 article (09/2020)
9.	Gong, Zhiyuan: 1 article (09/2020)
10.	Ho, Yi-Jung: 1 article (09/2020)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2023 - "WNK1 (WNK lysine deficient protein kinase 1) is a kind of protein kinase and participates in angiogenesis, having a potent tumor promoting role. " 01/01/2014 - "The WNK1 (WNK lysine deficient protein kinase 1) protein is a serine/threonine protein kinase with emerging roles in cancer. "
2.	Hepatocellular Carcinoma (Hepatoma) 01/01/2022 - "WNK lysine deficient protein kinase 1 (WNK1) has been shown to be highly expressed in hepatocellular carcinoma (HCC) samples and related to poor prognosis of HCC patients based on bioinformatics analysis. " 09/01/2020 - "Prognostic and Clinical Implications of WNK Lysine Deficient Protein Kinase 1 Expression in Patients With Hepatocellular Carcinoma."
3.	Hypertension (High Blood Pressure) 01/01/2019 - "Mutations in four genes, WNK lysine deficient protein kinase 1 and 4 (WNK1 and WNK4), kelch like family member 3 (KLHL3), or Cullin 3 (CUL3), can result in familial hyperkalemic hypertension (FHHt), a rare Mendelian form of human arterial hypertension. "
4.	Colonic Neoplasms (Colon Cancer) 02/01/2023 - "Aberrant expression of WNK lysine deficient protein kinase 1 is associated with poor prognosis of colon adenocarcinoma."

Related Drugs and Biologics

1.	Cullin Proteins (Cullins)
2.	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)
3.	Proteins (Proteins, Gene)
4.	Protein Kinases (Protein Kinase)