WNK Lysine-Deficient Protein Kinase 1

A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.

Also Known As:

WNK Lysine Deficient Protein Kinase 1

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        WNK Lysine-Deficient Protein Kinase 1: 5
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - WNK Lysine-Deficient Protein Kinase 1: 5
Biological Factors: 2472
- Antigens: 143924
  - Surface Antigens: 5813
    - Histocompatibility Antigens: 1132
      - Minor Histocompatibility Antigens: 395
        WNK Lysine-Deficient Protein Kinase 1: 5
  - Isoantigens: 1221
    - Histocompatibility Antigens: 1132
      - Minor Histocompatibility Antigens: 395
        WNK Lysine-Deficient Protein Kinase 1: 5

rat Wnk1 protein

Bio-Agent Context: Research Results