Short Chain Dehydrogenase-Reductases

A large family of oxidoreductases that are predominantly NAD- or NADP-dependent and 250 to 350 amino acids in length. They generally consist of two PROTEIN DOMAINS: A catalytic N-terminal domain that binds the substrate, and a C-terminal coenzyme-binding domain.

Also Known As:

Short Chain Dehydrogenase Family; Short Chain Dehydrogenase Superfamily; Short Chain Dehydrogenases; Short-Chain Alcohol Dehydrogenases; Alcohol Dehydrogenase, Short-Chain; Alcohol Dehydrogenases, Short-Chain; Chain Dehydrogenase, Short; Chain Dehydrogenase-Reductase, Short; Dehydrogenase, Short Chain; Dehydrogenase, Short-Chain Alcohol; Dehydrogenase-Reductase, Short Chain; Dehydrogenase-Reductases, Short Chain; Dehydrogenases, Short Chain; Dehydrogenases, Short-Chain Alcohol; Short Chain Alcohol Dehydrogenase; Short Chain Alcohol Dehydrogenases; Short Chain Dehydrogenase Reductase; Short Chain Dehydrogenase Reductases; Short Chain Dehydrogenase; Short Chain Dehydrogenase-Reductase; Short-Chain Alcohol Dehydrogenase

Networked: 36 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
        Short Chain Dehydrogenase-Reductases: 36
        WW Domain-Containing Oxidoreductase: 208
        human DHRS12 protein
        mouse Sdr16c5 protein
        mouse Sdr16c6 protein
        S cerevisiae Env9 protein

Experts

1.	Bhargavi, Gunapati: 2 articles (01/2022 - 01/2020)
2.	Palaniyandi, Kannan: 2 articles (01/2022 - 01/2020)
3.	Miura, Takeshi: 2 articles (07/2015 - 02/2013)
4.	Nishinaka, Toru: 2 articles (07/2015 - 02/2013)
5.	Terada, Tomoyuki: 2 articles (07/2015 - 02/2013)
6.	Han, Jianxiong: 1 article (01/2022)
7.	Patil, Shripad A: 1 article (01/2022)
8.	Qu, Min: 1 article (01/2022)
9.	Singh, Amit Kumar: 1 article (01/2022)
10.	Sun, Kai: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "In this study, we identified the tumor-suppressing role of DHRS2 (short-chain dehydrogenase/reductase family, member 2) at 14q11.2 in ESCCs. " 01/01/2013 - "Among these genes, two transcripts of the short chain dehydrogenase/reductase family 9C, member 7 (SDR9C7) were observed 7 times more frequently in N(+) compared with N(-) tumors. " 12/01/2011 - "WWOX acts as a tumor suppressor in human NSCLC models in a short-chain dehydrogenase/reductase domain-dependent manner. " 01/01/2022 - "In the current study, we explored how 2,4-Dienoyl-CoA reductase (DECR1), a short-chain dehydrogenase/reductase associated with mitochondrial and cytoplasmic compartments, promotes cancer cell growth. " 03/28/2014 - "The WW domain-containing oxidoreductase (WWOX) encodes a 46-kDa tumor suppressor that contains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain. "
2.	Prostatic Neoplasms (Prostate Cancer) 11/01/2015 - "Several microarray studies of prostate cancer (PCa) samples have suggested altered expression of the "orphan" enzyme short-chain dehydrogenase/reductase DHRS7 (retSDR4, SDR34C1). " 02/15/2001 - "This study identified a novel gene that we have designated prostate short-chain dehydrogenase/reductase 1 (PSDR1), that exhibits increased expression on exposure to androgens in the LNCaP prostate cancer cell line. " 02/15/2011 - "Levels of retinol dehydrogenase 5, and dehydrogenase/reductase short-chain dehydrogenase/reductase family member 9, which also convert androstanediol to DHT, were lower than 17β-HSD6 in prostate-derived cell lines and higher in the castration-recurrent human prostate cancer xenograft. "
3.	Infections 03/01/2012 - "Previous studies identified the Aedes aegypti (L.) (Diptera: Culicidae) mucin-like (AeIMUC1) and short-chain dehydrogenase/reductase (SDR) genes as midgut-expressed candidate genes influencing susceptibility to infection by Plasmodium gallinaceum (Brumpt). "
4.	Tuberculosis (Tuberculoses) 01/01/2022 - "During infection, Mycobacterium tuberculosis combats the stress generated by the host cells through the action of short-chain dehydrogenases/reductases (SDRs). " 01/01/2021 - "tuberculosis Rv0927c protein is predicted to be a short-chain dehydrogenase/reductase related to bacterial metabolism. " 01/01/2020 - "tuberculosis codes for short-chain dehydrogenases/reductases (SDRs). " 01/01/2016 - "intraperitoneal MDR multidrug-resistant NNAL 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol NNK 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone oaTOF orthogonal acceleration time-of-flight PBK physiologically based kinetic PCP pentachlorophenol SDR short-chain dehydrogenase/reductase SULT sulfotransferase TB tuberculosis."
5.	Mitochondrial Diseases (Mitochondrial Disease) 11/01/2007 - "Interaction of Abeta with Abeta-binding alcohol dehydrogenase (ABAD), a short-chain alcohol dehydrogenase in the mitochondrial matrix, leads to mitochondrial dysfunction evidenced by increased reactive oxygen species generation, mitochondrial membrane permeability formation and caspase-3-like activity induction, and decreased activities of the Krebs cycle. " 04/01/1999 - "Disorders of glycogen, lipid, or mitochondrial metabolism may cause three main clinical syndromes in muscle, namely, (1) progressive weakness with hypotonia (e.g., acid maltase, debrancher enzyme, and brancher enzyme deficiencies among the glycogenoses; carnitine uptake and carnitine acylcarnitine translocase defects among the fatty acid oxidation (FAO) defects; and cytochrome oxidase deficiency among the mitochondrial disorders) or (2) acute, recurrent, reversible muscle dysfunction with exercise intolerance and acute muscle breakdown or myoglobinuria (with or without cramps), e.g., phosphorylase, phosphofructokinase, and phosphoglycerate kinase among the glycogenoses and carnitine palmitoyltransferase II deficiency among the disorders of FAO or (3) both (e.g., long-chain or very long-chain acyl coenzyme A (CoA) dehydrogenase, short-chain L-3-hydroxyacyl-CoA dehydrogenase, and trifunctional protein deficiencies among the FAO defects). "

Related Drugs and Biologics

1.	Enzymes
2.	Mucins
3.	Androgens
4.	2,4-dienoyl-CoA reductase
5.	Oxidoreductases (Dehydrogenase)
6.	Proteins (Proteins, Gene)
7.	Anthracyclines
8.	Lipids
9.	Butyrates (Butyrate)
10.	Carbonyl Reductase (NADPH)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Castration