TRPA1 Cation Channel

A highly conserved, non-selective TRP cation channel that contains 14-17 ANKYRIN REPEATS. It functions in cold sensation and NOCICEPTION of endogenous inflammatory factors and volatile irritants. TRPA1 is also activated by CANNABINOIDS and may play a role in sound perception by hair cells of the inner ear.

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Networked: 177 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Geppetti, Pierangelo: 17 articles (11/2021 - 08/2008)
2.	Nassini, Romina: 16 articles (11/2021 - 08/2008)
3.	Materazzi, Serena: 12 articles (01/2020 - 08/2008)
4.	Pertovaara, Antti: 11 articles (11/2016 - 07/2009)
5.	Koivisto, Ari: 10 articles (01/2014 - 07/2009)
6.	De Logu, Francesco: 9 articles (11/2021 - 12/2014)
7.	Patacchini, Riccardo: 8 articles (12/2019 - 08/2008)
8.	Wei, Hong: 8 articles (11/2016 - 07/2009)
9.	Trevisan, Gabriela: 7 articles (08/2021 - 05/2014)
10.	Fusi, Camilla: 7 articles (01/2020 - 01/2012)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2022 - "In this work, we investigated the potential protection against Alzheimer's disease progression provided by early chronic pharmacological inhibition of the TRPA1 channel. " 01/01/2022 - "Astrocyte-neuron interplay is critical for Alzheimer's disease pathogenesis and is rescued by TRPA1 channel blockade." 04/27/2016 - "However, little is known about the significance of the TRPA1 channel in the pathophysiology of Alzheimer's disease (AD). " 01/01/2022 - "The toxic effect of amyloid-β on astrocytes triggered by TRPA1 channel activation is pivotal to Alzheimer's disease progression. " 01/01/2019 - "A biosensor was created for the simultaneous monitoring of endogenous H2 Sn and H2 S in mouse brains and exploring their roles in activation of the TRPA1 channel under two types of brain disease models: ischemia and Alzheimer's disease (AD). "
2.	Pain (Aches) 01/01/2023 - "Furthermore, quantitative sensory testing of A1 revealed an elevated heat-pain threshold but also, surprisingly, an elevated cold-pain threshold and extensive neurogenic inflammatory, flare, and pain responses following application of the TRPA1 channel activator mustard oil.CONCLUSIONOur study provides direct evidence in humans for pain-related functional changes linked to TRPV1, which is a prime target in the development of pain relievers.FUNDINGSupported by the Israel Science Foundation (368/19); Teva's National Network of Excellence in Neuroscience grant (no. 0394886) and Teva's National Network of Excellence in Neuroscience postdoctoral fellowship." 10/01/2023 - "Therefore, the focus of this paper is on the TRPV1/TRPA1 channel, and an analysis and summary of the processes and mechanism by which natural herbs activate TRPV1/TRPA1 to enhance GI motility and relieve pain are provided, which will lay the foundation for the development of natural herb treatments for this disease." 11/01/2021 - "Over the last 17 years since its cloning in 2003, the receptor-channel TRPA1 has received increasing attention due to its polymodal features and prominent role in pain signaling in a variety of human disease states. " 01/01/2020 - "Although transient receptor potential type A1 (TRPA1) channel is known to play roles in both acute and chronic itch and pain, whether DPH affects the activities of TRPA1 remains unclear. " 01/01/2019 - "This locus, Nociq4 (nociceptive sensitivity quantitative trait locus 4; MGI: 5661503), harbors the well-known pain gene Trpa1 (transient receptor potential cation channel, subfamily A, member 1). "
3.	Neurogenic Inflammation 03/29/2012 - "Recent studies revealed that the transient receptor potential A1 (TRPA1) channel is activated by a wide variety of substances that are released following tissue damage to evoke nociception and neurogenic inflammation. " 09/01/2011 - "Blockade of the spinal TRPA1 channel-mediated regulation of transmission may also attenuate cutaneous neurogenic inflammation." 09/01/2011 - "Additionally, blockade of the spinal TRPA1 channel reduced cutaneous neurogenic inflammation, presumably by decreasing drive of spinal interneurons that induce a proinflammatory dorsal root reflex. " 08/02/2010 - "Here we determine the cutaneous anti-inflammatory effect of a spinally administered TRPA1 channel antagonist to test the hypothesis that spinal TRPA1 channels contribute to cutaneous neurogenic inflammation induced by sustained noxious stimulation. " 07/01/2008 - "Two separate studies, the first recently reported in the JCI by Bessac et al. and the second reported by Andrè et al. in the current issue of the JCI (see the related article beginning on page 2574), have identified irritants that activate transient receptor potential cation channel, subfamily A, member 1 (TRPA1) receptors in airway sensory neurons, resulting in neurogenic inflammation and respiratory hypersensitivity. "
4.	Hypersensitivity (Allergy) 12/03/2015 - "Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is expressed in muscle afferents and direct activation of these receptors induces acute mechanical hypersensitivity. " 07/01/2012 - "Chembridge-5861528, a TRPA1 channel antagonist, was administered intaperitoneally (10-30 mg/kg), intraplantarly (10-30 μg), or intrathecally (10 μg) in attempts to suppress guarding and hypersensitivity. " 03/01/2010 - "Intrathecal (i.t.) administration of Chembridge-5861528 (CHEM, a TRPA1 channel antagonist) at doses 2.5-5.0 microg/rat markedly attenuated diabetic hypersensitivity, whereas 20 microg of CHEM was needed to produce a weak attenuation of diabetic hypersensitivity with intraplantar (i.pl.) administrations. " 03/01/2010 - "Previous results indicate that intaperitoneal administration of a TRPA1 channel antagonist attenuates diabetic hypersensitivity. " 07/01/2009 - "Prolonged antihypersensitivity effect after chronic treatment suggests that daily administration of a TRPA1 channel antagonist may prevent development of diabetic hypersensitivity."
5.	Inflammation (Inflammations) 01/01/2023 - "Inflammation-the role of TRPA1 channel." 07/21/2022 - "The TRPA1 channel is involved in a variety of physiological processes and its activation leads to pain perception and the development of inflammation. " 12/01/2020 - "We evaluated the TRPA1 channel contribution in inflammatory, oxidative, and proliferative states on skin inflammation induced by UVB radiation in mice. " 10/01/2017 - "Mustard oil (MO), a TRPA1 channel agonist, was injected into the whisker pads of rats to induce inflammation. " 01/01/2014 - "The transient receptor potential cation channel subfamily A, member 1 (TRPA1) is a cation channel with important functions in mediating cellular responses to noxious stimuli and inflammation. "

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5.	Paclitaxel (Taxol)
6.	Phosphoric Diester Hydrolases (Phosphodiesterases)
7.	Menthol
8.	prostaglandin-inositol cyclic phosphate
9.	diethylstilbestrol monophosphate (PDES)
10.	CTK 01512-2

Related Therapies and Procedures

1.	Therapeutics