A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals.
Also Known As:
Nitric Oxide Receptor; Nitric Oxide Receptors; Nitric Oxide-Sensitive Guanylyl Cyclase; Receptor, Nitric Oxide; Soluble Guanylate Cyclase; Soluble Guanylyl Cyclase, alpha Subunit; Soluble Guanylyl Cyclase, beta Subunit; Cyclase, Soluble Guanylate; Cyclase, Soluble Guanylyl; Guanylate Cyclase, Soluble; Guanylyl Cyclase, Soluble; Nitric Oxide Sensitive Guanylyl Cyclase; Oxide Receptor, Nitric; Oxide Receptors, Nitric