RNA Demethylase AlkB Homolog 5

A dioxygenase and alkylation repair homolog that demethylates RNA by oxidative demethylation. It specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA in higher eukaryotes. It can also demethylate N(6)-methyladenosine in SINGLE-STRANDED DNA.

Also Known As:

AlkB Homolog 5, RNA Demethylase; Alkylated DNA Repair Protein AlkB Homolog 5; Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 5; RNA Demethylase ALKBH5; ALKBH5, RNA Demethylase; Alpha Ketoglutarate Dependent Dioxygenase AlkB Homolog 5; Demethylase ALKBH5, RNA

Networked: 26 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cai, Zhen: 2 articles (01/2022 - 01/2022)
2.	Cao, Wen: 2 articles (01/2022 - 01/2022)
3.	Chen, Jing: 2 articles (01/2022 - 01/2020)
4.	He, Jingsong: 2 articles (01/2022 - 01/2022)
5.	Hou, Yifan: 2 articles (01/2022 - 01/2022)
6.	Liu, Yang: 2 articles (01/2022 - 01/2022)
7.	Qu, Jianwei: 2 articles (01/2022 - 01/2022)
8.	Zhang, Enfan: 2 articles (01/2022 - 01/2022)
9.	Gan, Haili: 1 article (10/2022)
10.	Jin, Liping: 1 article (10/2022)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2020 - "Genistein Ameliorates Renal Fibrosis Through Regulation Snail via m6A RNA Demethylase ALKBH5."
2.	Carcinogenesis 01/01/2020 - "RNA demethylase ALKBH5 promotes ovarian carcinogenesis in a simulated tumour microenvironment through stimulating NF-κB pathway." 08/01/2023 - "RNA demethylase ALKBH5 suppresses tumorigenesis via inhibiting proliferation and invasion and promoting CD8+ T cell infiltration in colorectal cancer." 01/01/2022 - "RNA demethylase ALKBH5 promotes tumorigenesis in multiple myeloma via TRAF1-mediated activation of NF-κB and MAPK signaling pathways." 01/01/2020 - "RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia." 03/10/2023 - "RNA demethylase ALKBH5 promotes tumorigenesis of t (8;21) acute myeloid leukemia via ITPA m6A modification."
3.	Neoplasms (Cancer) 01/01/2022 - "RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential." 01/01/2022 - "Silencing the m6A demethylase alkB homolog 5, RNA demethylase (ALKBH5) suppresses tumor progression in vitro and in vivo. " 01/01/2020 - "Among the top-ranked off-targets of MV1035, we focused on the RNA demethylase ALKBH5 enzyme, known for playing a key role in cancer. " 01/01/2019 - "Mechanistically, it was found that GAS5-AS1 interacted with the tumor suppressor GAS5, and increased its stability by interacting with RNA demethylase ALKBH5 and decreasing GAS5 N6-methyladenosine (m6A) modification. " 03/05/2021 - "AlkB homolog 5 RNA demethylase (ALKBH5), an m6A demethylase, belongs to the AlkB family of dioxygenases and has been shown to specifically demethylate m6A in RNA, which is associated with a variety of tumors. "
4.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2020 - "RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia." 03/10/2023 - "RNA demethylase ALKBH5 promotes tumorigenesis of t (8;21) acute myeloid leukemia via ITPA m6A modification."
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2023 - "RNA demethylase ALKBH5 promotes colorectal cancer progression by posttranscriptional activation of RAB5A in an m6A-YTHDF2-dependent manner." 08/01/2023 - "RNA demethylase ALKBH5 suppresses tumorigenesis via inhibiting proliferation and invasion and promoting CD8+ T cell infiltration in colorectal cancer."

Related Drugs and Biologics

1.	6-methyladenine
2.	Genistein
3.	RNA (Ribonucleic Acid)
4.	Methyltransferases
5.	N-methyladenosine
6.	Sirolimus (Rapamycin)
7.	RNA-Binding Proteins (RNA-Binding Protein)
8.	Transcription Factors (Transcription Factor)
9.	Proteins (Proteins, Gene)
10.	Phosphotransferases (Kinase)