Degloving Injuries

Avulsions of the superficial tissues of SKIN and SUBCUTANEOUS TISSUE from the underlying FASCIA.

Also Known As:

Degloving Wounds; Skin Avulsion; Skin Avulsion Injuries; Avulsion Injuries, Skin; Avulsion Injury, Skin; Avulsion, Skin; Avulsions, Skin; Degloving Injury; Degloving Wound; Injuries, Degloving; Injuries, Skin Avulsion; Injury, Degloving; Injury, Skin Avulsion; Skin Avulsion Injury; Skin Avulsions; Wound, Degloving; Wounds, Degloving

Networked: 193 relevant articles (10 outcomes, 10 trials/studies)

Relationship Network

Disease Context: Research Results

Wounds and Injuries: 176426
- Soft Tissue Injuries: 1075
  - Degloving Injuries: 193

Related Diseases

1.	Degloving Injuries
2.	Wounds and Injuries (Trauma)
3.	Sepsis (Septicemia)
4.	Inflammation (Inflammations)
5.	Edema (Dropsy)

Experts

1.	Hao, Ruizheng: 5 articles (06/2022 - 11/2016)
2.	Huo, Yongxin: 5 articles (06/2022 - 11/2016)
3.	Wang, Hui: 5 articles (06/2022 - 12/2018)
4.	Wang, Bin: 4 articles (06/2022 - 11/2016)
5.	Gao, Weiyang: 4 articles (09/2019 - 05/2012)
6.	Wang, Wei: 3 articles (06/2022 - 07/2003)
7.	Li, Zhijie: 3 articles (09/2019 - 05/2012)
8.	Yan, Hede: 3 articles (09/2019 - 05/2012)
9.	Chi, Zhenglin: 3 articles (07/2017 - 05/2012)
10.	Hou, Ruixing: 3 articles (12/2016 - 10/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Degloving Injuries:

1.	Pentoxifylline (Trental)FDA LinkGeneric 07/01/2006 - "In histopathological examination, loss of superficial ephitelium and dense infiltration of inflammatory cells were seen in groups 1 and 2, and the skin layers were normal in the group 3. Pentoxifylline improved tissue preservation and was proved to be highly beneficial in treatment of skin degloving injuries." 07/01/2006 - "In this pilot study, we attempted to develop an experimental model for degloving injuries and investigated the efficacy of pentoxifylline, a well-known potent agent in enhancement of erythrocyte flexibility and tissue vascularization, in treatment of this injury model. " 07/01/2006 - "The effect of pentoxifylline in treatment of skin degloving injuries: an experimental study." 03/01/2013 - "An experimental model reproducing a degloving injury of the hind limb of rats was developed in our department, and the effects of pentoxifylline (Ptx) and allopurinol (Alp) were assessed. " 03/01/2013 - "Experimental model of degloving injury in rats: effect of allopurinol and pentoxifylline in improving viability of avulsed flaps."
2.	Enoxaparin (Lovenox)FDA LinkGeneric 01/01/2014 - "Rivaroxaban and enoxaparin improved tissue survival in skin degloving injuries in terms of gross morphological and histopathological findings in a rat tail model." 01/01/2014 - "We encountered positive effects of both heparin and enoxaparin on the treatment of degloving injuries in this experimental study. " 01/01/2014 - "Effects of enoxaparin and rivaroxaban on tissue survival in skin degloving injury: an experimental study." 01/01/2014 - "We aimed to compare the effects of heparin and enoxaparin, which are used as standard treatment, on viability in degloving injuries. " 01/01/2014 - "Analysis of the effects of heparin and enoxaparin on degloving injuries."
3.	Fondaparinux (Arixtra)FDA Link 05/01/2020 - "Dabigatran and fondaparinux improved tissue survival in skin degloving injuries concerning gross morphological and histopathological findings. " 05/01/2020 - "Effects of dabigatran and fondaparinux on degloving injuries: An experimental study." 05/01/2020 - "We hypothesized that the anticoagulant pharmacological agents, fondaparinux and dabigatran may be beneficial in the treatment of degloving injuries by enhancing the viability of the reattached flap. "
4.	Dabigatran FDA Link 05/01/2020 - "Dabigatran and fondaparinux improved tissue survival in skin degloving injuries concerning gross morphological and histopathological findings. " 05/01/2020 - "Effects of dabigatran and fondaparinux on degloving injuries: An experimental study." 05/01/2020 - "We hypothesized that the anticoagulant pharmacological agents, fondaparinux and dabigatran may be beneficial in the treatment of degloving injuries by enhancing the viability of the reattached flap. "
5.	RivaroxabanIBA 01/01/2014 - "Rivaroxaban and enoxaparin improved tissue survival in skin degloving injuries in terms of gross morphological and histopathological findings in a rat tail model." 01/01/2014 - "Effects of enoxaparin and rivaroxaban on tissue survival in skin degloving injury: an experimental study." 01/01/2014 - "The aim of this study was to evaluate the effects of the antithrombotic agents enoxaparin and rivaroxaban on tissue survival following skin degloving injury in an experimental rat tail model. "
6.	AnticoagulantsIBA 05/01/2020 - "We hypothesized that the anticoagulant pharmacological agents, fondaparinux and dabigatran may be beneficial in the treatment of degloving injuries by enhancing the viability of the reattached flap. "
7.	sivelestatIBA 01/01/2020 - "The anti-inflammatory effects of Sivelestat will be beneficial for decreasing the early complications of degloving injury, such as inflammation, sepsis, and edema, better than Pentoxifylline, which exerts only hemorheological effects."
8.	SolutionsIBA 09/01/2011 - "In this study, we present a 1-flap solution to treat degloving injuries of the hand and fingers. " 01/01/2002 - "Re-plantation is the solution of choice for such degloving injuries, but a different flap can be used if replantation is not possible. "
9.	Heparin (Liquaemin)FDA LinkGeneric 01/01/2017 - "Effects of heparin and hyperbaric oxygenation on necrosis reduction in an animal model for degloving injuries." 01/01/2014 - "We encountered positive effects of both heparin and enoxaparin on the treatment of degloving injuries in this experimental study. " 01/01/2014 - "We aimed to compare the effects of heparin and enoxaparin, which are used as standard treatment, on viability in degloving injuries. " 01/01/2014 - "Analysis of the effects of heparin and enoxaparin on degloving injuries."
10.	Oxygen (Dioxygen)IBA 05/01/2013 - "The aim of this study was to investigate the effect of hyperbaric oxygen (HBO) therapy on healing in an experimental model of a degloving injury of the tails of nicotine-treated rats. "

Therapies and Procedures

1.	Surgical Amputation (Amputations) 02/01/2023 - "In this study, a reverse homodigital dorsal wraparound flap innervated by the dorsal digital nerve was devised to repair degloving injury or amputation of distal thumb in 20 consecutive cases. " 10/01/2023 - "Weekend presentation may impact interventions received and amputation risk in patients presenting with open extremity degloving injuries." 08/01/2023 - "We present a case involving an adolescent patient involved in an industrial farm tractor rollover with substantial crush and degloving injuries requiring bilateral lower extremity amputations. " 01/01/2023 - "Degloving injuries occurred in two patients, and finger amputations occurred in eight others. " 12/15/2018 - "Between June 2011 and September 2016, 9 cases of thumb degloving injury were treated with amputation and Ilizarov technology. "
2.	Negative-Pressure Wound Therapy 10/01/2014 - "The purpose of this study is to explore the clinical effects of negative pressure wound therapy (NPWT) and external fixation in the treatment of femur fracture complicated by skin avulsion. " 03/30/2021 - "Although the majority of heel pad degloving injuries have a poor prognosis, there are positive prognostic factors as presented in the current case for a satisfying functional final outcome, which include vascular intergrity, fracture stabilization, soft-tissue reconstruction with negative pressure wound therapy, and application of skin grafts." 12/01/2020 - "Management of a Severe Degloving Injury With a Type 2 Open Tibia Fracture Using Negative Pressure Wound Therapy With Instillation and Dwell Time." 12/01/2020 - "Skin grafts harvested from avulsed flaps may be used to treat degloving injuries, while negative pressure wound therapy (NPWT) is used to secure the grafts. " 12/26/2019 - "Reconstruction of massive skin avulsion of the scrota and penis by combined application of dermal regeneration template (Pelnac) and split-thickness skin graft with vacuum-assisted closure: A case report."
3.	Therapeutics 07/01/2016 - "Vacuum therapy is an effective and safe treatment of degloving injuries. " 04/01/2002 - "Vacuum therapy in degloving injuries of the foot: technical refinements." 08/01/1997 - "It goes without saying that the optimal therapy for reconstruction of degloving injuries is to employ the tissues that were avulsed. " 10/01/1970 - "[Pathology and therapy of degloving injury]." 06/01/2012 - "The authors present an innovative technique of treating degloving injuries with cryopreserved split-thickness skin grafts harvested from degloved flap, artificial dermal replacement and vacuum-assisted closure (VAC therapy). "
4.	Surgical Flaps 09/16/2020 - "To examine the efficacy of combination of the reverse dorsoradial flap of the thumb and middle finger proper digital arterial island flap for repair of distal thumb degloving injury. " 01/01/2023 - "Fingertip degloving injury coverage with homodactyle bipedicled dorsal island flap." 01/01/2022 - "Skin avulsion-injury models were established by avulsing 10×4 cm pedicled flaps on porcine hindlimbs. " 01/20/2021 - "Conclusions: The operation is simple and reliable for dorsal branch of digital artery pedicled flap combined with V-Y advancement flap to repair the degloving injury of fingertip, and reverse dorsal metacarpal recurrent artery pedicled island flaps to repair the soft tissue defects in the donor sites of the proximal dorsum, and the appearance and function of the affected fingers recover well, with minimal injury. " 01/20/2021 - "Objective: To investigate the effects of the dorsal branch of digital artery pedicled flap combined with V-Y advancement flap for repair of degloving injury of fingertip and reverse dorsal metacarpal recurrent artery pedicled island flap for relaying repair of the soft tissue defects in the donor sites of the proximal dorsum. "
5.	Skin Transplantation (Skin Grafting) 07/01/2023 - "The gold standard treatment for degloving injuries is using skin grafting and flap. " 09/01/2019 - "The management of degloving injuries of the limb with full thickness skin grafting using vacuum sealing drainage or traditional compression dressing: A comparative cohort study." 07/01/2009 - "Use of a hypogastric flap and split-thickness skin grafting for a degloving injury of the penis and scrotum: A different approach." 04/01/1997 - "In order to utilize avulsed skin to cover skin defects, a new skin grafting technique, thin split thickness skin grafting double taken from avulsed skin, was used in 23 cases of severe skin avulsion. " 04/01/1997 - "[Thin split thickness skin grafting double taken from avulsed skin in treatment for skin avulsion in children]."