Cobicistat

A carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which it is used in combination, for the treatment of HIV INFECTIONS.

Also Known As:

Networked: 138 relevant articles (13 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	DeJesus, Edwin: 8 articles (01/2020 - 03/2011)
2.	Das, Moupali: 7 articles (12/2020 - 11/2016)
3.	Liu, Hui C: 7 articles (11/2016 - 03/2011)
4.	Szwarcberg, Javier: 6 articles (04/2016 - 06/2012)
5.	Sax, Paul E: 5 articles (12/2020 - 06/2012)
6.	Piontkowsky, David: 5 articles (10/2019 - 07/2014)
7.	Fordyce, Marshall W: 5 articles (02/2017 - 04/2013)
8.	Cheng, Andrew K: 5 articles (06/2015 - 06/2012)
9.	Cohen, Calvin: 5 articles (03/2014 - 03/2011)
10.	Castagna, Antonella: 4 articles (01/2021 - 01/2017)

Related Diseases

1.	HIV Infections (HIV Infection) 06/01/2016 - "Cobicistat is a pharmacokinetic booster in several fixed-dose combination products for treatment of human immunodeficiency virus (HIV) infection. " 09/01/2015 - "Cobicistat: Review of a Pharmacokinetic Enhancer for HIV Infection." 07/01/2018 - "However, recent data from trials that have investigated the new DRV/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) combination showed an excellent efficacy and tolerability of this coformulation both in naïve patients and in those with viral suppression, making D/C/F/TAF a new option for the treatment of HIV infection. " 04/05/2021 - "Darunavir ethanolate (DRV) and Cobicistat (CBS) is a combination of antiretroviral drugs used for the treatment of human immunodeficiency virus (HIV) infections. " 01/01/2017 - "Atazanavir sulfate + cobicistat for the treatment of HIV infection."
2.	Infections 10/01/2013 - "Cobicistat: a new boost for the treatment of human immunodeficiency virus infection." 07/01/2012 - "The development of cobicistat and the new once-daily INSTIs may revolutionize the treatment of human immunodeficiency virus type 1 infection. " 01/01/2020 - "Safety, pharmacokinetics, and efficacy of GSK2838232 boosted by cobicistat were evaluated in individuals with HIV-1 infection. " 01/01/2019 - "The aim of the study was to evaluate darunavir and cobicistat pharmacokinetics in pregnant women with HIV-1 infection. " 01/01/2017 - "Areas covered: Atazanavir sulfate + cobicistat (ATV/c) was recently approved for the treatment of HIV-1 infection. "
3.	COVID-19 08/01/2020 - "There are currently no definitive data on the safety and efficacy of DRV/cobicistat for the treatment of COVID-19. " 01/01/2022 - "These data highlight cobicistat as a therapeutic candidate for treating SARS-CoV-2 infection and as a potential building block of combination therapies for COVID-19. " 10/01/2021 - "After extensive computational studies, we propose that Cobicistat and Hopeaphenol show potential to be excellent drugs that can form the basis of treating COVID-19 disease.Communicated" 12/29/2020 - "In conclusion, cobicistat, which is already an FDA-approved drug being used against HIV, may serve as a good inhibitor against the main protease of SARS-CoV-2 that, in turn, can help in combating COVID-19, and these results can also form the basis for the rational structure-based drug design against COVID-19." 01/01/2021 - "Therefore, a clinical trial of cobicistat-abacavir-rilpivirine on a limited number of COVID-19 patients in moderately severe and severe condition is warranted."
4.	Chronic Hepatitis B 11/01/2016 - "Coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide (E/C/F/TAF) has high efficacy and improved renal and bone safety in multiple phase 3 trials; TAF single agent is being studied in 2 phase 3 trials in patients with chronic hepatitis B. "
5.	Coinfection 07/01/2019 - "Evaluation of Safety and Effectiveness of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Switch Followed by Ledipasvir/Sofosbuvir HCV Therapy in HIV-HCV Coinfection." 05/01/2023 - "Isoniazid/rifampin for COVID-19 and tuberculosis co-infection; lopinavir/ritonavir and cobicistat/remdesivir combination therapy; or multi-drug therapy including ivermectin, azithromycin, montelukast and acetylsalicylic acid, known as TNR4 therapy, all improved recovery in patients with COVID-19. "

Related Drugs and Biologics

1.	elvitegravir
2.	Emtricitabine (Emtriva)
3.	Tenofovir (Viread)
4.	Ritonavir (Norvir)
5.	Tablets
6.	tenofovir alafenamide
7.	Creatinine
8.	Protease Inhibitors (Protease Inhibitor)
9.	Ivermectin (Mectizan)
10.	remdesivir

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Art Therapy
4.	Highly Active Antiretroviral Therapy (HAART)
5.	Bariatric Surgery