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NMS-E973

structure in first source

Also Known As:

5-(2,4-dihydroxy-6-(4-nitrophenoxy)phenyl)-N-(1-methylpiperidin-4-yl)-isoxazole-3-carboxamide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - NMS-E973: 2

Experts

1.	Chi, Guonan: 1 article (01/2018)
2.	Jin, Xingyi: 1 article (01/2018)
3.	Sun, Libo: 1 article (01/2018)
4.	Yang, Shoujun: 1 article (01/2018)
5.	Ballinari, Dario: 1 article (07/2013)
6.	Brasca, Maria G: 1 article (07/2013)
7.	Casale, Elena: 1 article (07/2013)
8.	Ciomei, Marina: 1 article (07/2013)
9.	De Ponti, Anna: 1 article (07/2013)
10.	Degrassi, Anna: 1 article (07/2013)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Furthermore, PUMA was induced by NMS-E973 treatment in xenograft tumors, and deficiency in PUMA significantly suppressed the antitumor effects of NMS-E973. " 07/01/2013 - "Overall, the efficacy profile of NMS-E973 suggests a potential for development in different clinical settings, including tumors that have become resistant to molecular targeted agents, particularly in cases of tumors which reside beyond the BBB." 07/01/2013 - "NMS-E973 induces tumor shrinkage in different human tumor xenografts, and is highly active in models of resistance to kinase inhibitors. "
2.	Neoplasm Metastasis (Metastasis) 07/01/2013 - "NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases."
3.	Melanoma (Melanoma, Malignant) 07/01/2013 - "Moreover, consistent with its brain penetration, NMS-E973 is active also in an intracranially implanted melanoma model. "
4.	Glioblastoma (Glioblastoma Multiforme) 01/01/2018 - "As a proapoptotic Bcl-2 member, PUMA was induced by NMS-E973 in a p53-dependent manner in glioblastoma in cell culture, thereby inducing apoptosis in glioblastoma cells. " 01/01/2018 - "We found that NMS-E973 induces apoptosis and inhibits cell growth in glioblastoma cells in cell culture and xenograft models. " 01/01/2018 - "Hsp90 inhibitor NMS-E973 exerts the anticancer effect against glioblastoma via induction of PUMA-mediated apoptosis."

Related Drugs and Biologics

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