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hydroxybupropion

active metabolite of bupropion; structure in first source

Also Known As:

4-hydroxy bupropion

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - Propiophenones: 1
    - Bupropion: 1588
      - hydroxybupropion: 8

Experts

1.	Blough, Bruce E: 2 articles (09/2010 - 06/2010)
2.	Carroll, F Ivy: 2 articles (09/2010 - 06/2010)
3.	Damaj, M Imad: 2 articles (09/2010 - 06/2010)
4.	Lukas, Ronald J: 2 articles (09/2010 - 06/2010)
5.	Chang, Cheng-Chen: 1 article (03/2017)
6.	Hsu, Wen-Yu: 1 article (03/2017)
7.	Ma, Szu-Pin: 1 article (03/2017)
8.	Tsai, Chia-Jui: 1 article (03/2017)
9.	Al-Abri, S A: 1 article (12/2013)
10.	Benowitz, N L: 1 article (12/2013)

Related Diseases

1.	Tobacco Use Disorder (Nicotine Dependence) 09/01/2010 - "Because bupropion metabolism is more similar in humans and mice than in humans and rats, the present study investigated effects of hydroxybupropion enantiomers in mouse behavioral models measuring various aspects of nicotine dependence. "
2.	Cardiotoxicity 12/01/2013 - "Cardiotoxicity appears to be caused primarily by bupropion rather than its active metabolite hydroxybupropion." 12/01/2013 - "Delayed bupropion cardiotoxicity associated with elevated serum concentrations of bupropion but not hydroxybupropion."
3.	Chronic Kidney Failure (Chronic Renal Failure) 01/01/2004 - "The pharmacokinetics of BP and two of its major metabolites, hydroxybupropion (HB) and threohydrobupropion (TB) were studied in 8 smokers with ESRD receiving haemodialysis. "
4.	Kidney Diseases (Kidney Disease) 06/01/2010 - "Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases."
5.	Delirium 03/01/2017 - "An increased level of hydroxybupropion may cause the elevation of dopamine and a risk of subsequent delirium. "

Related Drugs and Biologics

1.	Bupropion (Wellbutrin)
2.	Cytochrome P-450 CYP2B6 (CYP2B6)
3.	Rifampin (Rifampicin)
4.	Naltrexone (ReVia)
5.	Dopamine (Intropin)
6.	Smoking Cessation Agents
7.	hydrobupropion

Related Therapies and Procedures

1.	Aftercare (After-Treatment)