Member 1 Solute Carrier Family 12

Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS such as FUROSEMIDE; and BUMETANIDE. Mutations in the gene encoding SLC12A1 are associated with a BARTTER SYNDROME.

Also Known As:

Solute Carrier Family 12, Member 1; BSC1 Transport Protein; Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2; Kidney-Specific Na-K-Cl Symporter; NKCC2 Cotransporter; NKCC2 Protein; SLC12A1 Cotransporter; SLC12A1 Protein; Cotransporter, NKCC2; Cotransporter, SLC12A1; Kidney Specific Na K Cl Symporter; Na-K-Cl Symporter, Kidney-Specific; Protein, BSC1 Transport; Protein, NKCC2; Protein, SLC12A1; Symporter, Kidney-Specific Na-K-Cl; Transport Protein, BSC1

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Symporters: 1442
        Solute Carrier Family 12: 13
        Sodium-Potassium-Chloride Symporters: 109
        Member 1 Solute Carrier Family 12: 37
      - Solute Carrier Proteins: 34
        Sodium-Potassium-Chloride Symporters: 109
        Member 1 Solute Carrier Family 12: 37
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Symporters: 1442
        Sodium-Potassium-Chloride Symporters: 109
        Member 1 Solute Carrier Family 12: 37
      - Solute Carrier Proteins: 34
        Sodium-Potassium-Chloride Symporters: 109
        Member 1 Solute Carrier Family 12: 37

human SLC12A1 protein

Bio-Agent Context: Research Results