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CGI 1746

inhibits Bruton's protein kinase (Btk); structure in first source

Also Known As:

CGI-1746; CGI1746

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Conklin, Douglas S: 2 articles (01/2016 - 01/2015)
2.	Kokabee, Leila: 2 articles (01/2016 - 01/2015)
3.	Sevinsky, Christopher J: 2 articles (01/2016 - 01/2015)
4.	Wang, Xianhui: 2 articles (01/2016 - 01/2015)
5.	Khan, Faiza: 1 article (01/2016)
6.	Sun, Yan: 1 article (01/2016)
7.	Wong, Jason: 1 article (01/2016)
8.	Das, Satyabrata: 1 article (02/2015)
9.	Franqui, Reinaldo: 1 article (02/2015)
10.	Gu, Zhimin: 1 article (02/2015)

Related Diseases

1.	Arthritis (Polyarthritis) 01/01/2011 - "Using CGI1746, we demonstrate that Btk regulates inflammatory arthritis by two distinct mechanisms. " 01/01/2011 - "Accordingly, in myeloid- and FcγR-dependent autoantibody-induced arthritis, CGI1746 decreases cytokine levels within joints and ameliorates disease. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "In this study, we show that recently developed inhibitors of BTK, such as ibrutinib (PCI-32765), AVL-292, and CGI-1746, reduce breast cancer cell survival and prevent drug-resistant clones from arising. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2015 - "Down regulation of this protein with RNAi or inhibition with BTK-specific inhibitors, Ibrutinib, AVL-292 or CGI-1746 decrease cell survival and induce apoptosis in prostate cancer cells. "
4.	Neoplasms (Cancer) 02/01/2015 - "Furthermore, overexpression of BTK in myeloma cells promoted tumor growth in laboratory mice and rendered side population-derived tumors that contained high levels of BTK more sensitive to the selective, second-generation BTK inhibitor, CGI1746, than side population-derived tumors that harbored low levels of BTK. "
5.	Experimental Arthritis 01/01/2011 - "CGI1746 blocks B cell receptor-dependent B cell proliferation and in prophylactic regimens reduces autoantibody levels in collagen-induced arthritis. "

Related Drugs and Biologics

1.	Cytokines
2.	Autoantibodies
3.	ibrutinib
4.	Proteins (Proteins, Gene)