((7R)- 7- (((4- fluorophenyl)sulfonyl)(methyl)amino)- 6,7,8,9- tetrahydropyrido(1,2- a)indol- 10- yl)acetic acid

a chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) and prostaglandin D2 receptor antagonist; structure in first source

Also Known As:

MK-7246

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Carbolines: 283
      - ((7R)-7-(((4-fluorophenyl)sulfonyl)(methyl)amino)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)acetic acid: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Carbolines: 283
        ((7R)-7-(((4-fluorophenyl)sulfonyl)(methyl)amino)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)acetic acid: 4
  - 3-Ring Heterocyclic Compounds
    - Carbolines: 283
      - ((7R)-7-(((4-fluorophenyl)sulfonyl)(methyl)amino)-6,7,8,9-tetrahydropyrido(1,2-a)indol-10-yl)acetic acid: 4

Experts

1.	Gervais, Francois G: 2 articles (11/2014 - 01/2011)
2.	Crackower, Michael A: 2 articles (01/2011 - 01/2011)
3.	Denis, Danielle: 2 articles (01/2011 - 01/2011)
4.	Gallant, Michel: 2 articles (01/2011 - 01/2011)
5.	Hamel, Martine: 2 articles (01/2011 - 01/2011)
6.	O'Neill, Gary P: 2 articles (01/2011 - 01/2011)
7.	Sawyer, Nicole: 2 articles (01/2011 - 01/2011)
8.	Sillaots, Susan: 2 articles (01/2011 - 01/2011)
9.	Slipetz, Deborah: 2 articles (01/2011 - 01/2011)
10.	Stocco, Rino: 2 articles (01/2011 - 01/2011)

Related Diseases

1.	Respiratory Tract Diseases (Respiratory Tract Disease) 01/01/2011 - "Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases." 07/01/2012 - "MK-7246, an antagonist of the chemoattractant receptor on T helper type 2 (Th2) cells, is being developed for the treatment of respiratory diseases. "
2.	Respiratory Hypersensitivity 01/01/2011 - "We show that MK-7246 1) has high affinity for the human, monkey, dog, rat, and mouse CRTH2, 2) interacts with CRTH2 in a reversible manner, 3) exhibits high selectivity over all prostanoid receptors as well as 157 other receptors and enzymes, 4) acts as a full antagonist on recombinant and endogenously expressed CRTH2, 5) demonstrates good oral bioavailability and metabolic stability in various animal species, 6) yields ex vivo blockade of CRTH2 on eosinophils in monkeys and sheep, and 7) significantly blocks antigen-induced late-phase bronchoconstriction and airway hyper-responsiveness in sheep. "
3.	Pneumonia (Pneumonitis) 11/15/2014 - "Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation."

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