carolacton

damages biofilms; isolated from Sorangium cellulosum; structure in first source

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

1.	Donner, Jannik: 4 articles (11/2017 - 11/2016)
2.	Reck, Michael: 4 articles (11/2017 - 11/2016)
3.	Wagner-Döbler, Irene: 4 articles (11/2017 - 11/2016)
4.	Müller, Rolf: 3 articles (11/2017 - 11/2016)
5.	Kirschning, Andreas: 3 articles (10/2017 - 11/2016)
6.	Fu, Chengzhang: 1 article (11/2017)
7.	Herrmann, Jennifer: 1 article (11/2017)
8.	Koehnke, Jesko: 1 article (11/2017)
9.	Sikandar, Asfandyar: 1 article (11/2017)
10.	Zaburannyi, Nestor: 1 article (11/2017)

1.	Endocarditis 10/18/2017 - "Carolacton, a secondary metabolite isolated from the extracts of Sorangium cellulosum, causes membrane damage and cell death in biofilms of the caries- and endocarditis-associated bacterium Streptococcus mutans and Streptococcus pneumoniae. " 09/01/2017 - "The myxobacterial secondary metabolite carolacton inhibits growth of Streptococcus pneumoniae and kills biofilm cells of the caries- and endocarditis-associated pathogen Streptococcus mutans at nanomolar concentrations. " 05/28/2015 - "Carolacton, a secondary metabolite isolated from the extracts of Sorangium cellulosum, causes membrane damage and cell death in biofilms of the caries- and endocarditis-associated bacterium Streptococcus mutans. "
2.	Pneumonia (Pneumonitis) 11/01/2016 - "The clinical pneumonia isolate Sp49 showed immediate growth arrest and cell lysis, suggesting a bacteriolytic effect of Carolacton. "
3.	Pneumococcal Infections 11/01/2016 - "Our data show that Carolacton might have potential for treating pneumococcal infections."
4.	Neoplasms (Cancer) 11/16/2017 - "As mitochondrial MTHFD2 is known to be upregulated in cancer cells, it may be possible to use carolacton as an inhibitor tool compound to assess MTHFD2 as an anti-cancer target." 11/16/2017 - "We show that the human FolD orthologs, MTHFD1 and MTHFD2, are also inhibited in the low nM range, and that micromolar concentrations of carolacton inhibit the growth of cancer cell lines. "