Autoimmune oophoritis

08/01/1995 - "Our findings suggest that murine experimental autoimmune oophoritis develops independently of gonadotropin stimulation of the ovary."
08/01/1995 - "Murine experimental autoimmune oophoritis develops independently of gonadotropin stimulation and is primarily localized in the stroma and theca."
08/01/1995 - "Here we examine the possibility that gonadotropin stimulation of the ovary plays a role in the development of post-thymectomy autoimmune oophoritis. "
03/01/1990 - "Possible explanations include restoration of down-regulated gonadotropin receptors by development of a prolactinoma, spontaneous remission of autoimmune oophoritis, or prior tumor secretion of biologically inert gonadotropins."

03/01/1990 - "Possible explanations include restoration of down-regulated gonadotropin receptors by development of a prolactinoma, spontaneous remission of autoimmune oophoritis, or prior tumor secretion of biologically inert gonadotropins."

08/01/2002 - "This unit describes the immunologic properties of the ZP3 peptides, the method of active autoimmune oophoritis induction, and the evaluation and semiquantitation of ovarian pathology. "
01/01/1992 - "The identification of a well characterized peptide as a causative agent of autoimmune oophoritis should facilitate understanding of the pathogenesis of this T cell-mediated autoimmune disease. "
08/01/2006 - "Immunization of SWXJ female mice with the p215-234 peptide derived from mouse inhibin-alpha activates CD4(+) T cells and induces experimental autoimmune oophoritis with a unique biphasic phenotype characterized by an early stage of enhanced fertility followed by a delayed stage of POF. "
12/01/1995 - "Pathogenic T cells responsible for autoimmune oophoritis can be activated through stimulation by non-ovarian peptides that cross-react with self ovarian peptides at the level of the T cell receptor. "
12/01/1995 - "Based on peptide induction of autoimmune oophoritis and T cell-dependent amplified autoantibody response to ovarian ZP, cross-reaction was documented for 7 (or 44%) of the 16 nonovarian peptides studied. "

08/01/2007 - "The severity of autoimmune oophoritis and the titer of ZP autoantibodies were also significantly reduced. "
10/01/2005 - "We obtained a histologic diagnosis of autoimmune oophoritis in four women who tested positive for adrenal cortex autoantibodies and excluded this diagnosis in ovarian biopsies from six women who tested negative for adrenal cortex autoantibodies (4/4 vs. 0/6). "
10/01/2005 - "Serum adrenal cortex autoantibodies assessed by indirect immunofluorescence and autoimmune oophoritis assessed by immunohistochemical lymphocyte markers. "
09/01/1992 - "These histological features of the present case are typical of autoimmune oophoritis although the presence of autoantibodies and hormonal level in the patient's serum were unknown. "
10/01/2005 - "In women who present with 46,XX spontaneous premature ovarian failure as their primary concern there is a clear association between serum adrenal cortex autoantibodies and the presence of histologically confirmed autoimmune oophoritis."

01/01/2015 - "We found that AMHR2-CD immunization of C57BL/6 females induced a prominent antigen-specific proinflammatory CD4+ T cell response that resulted in a mild transient autoimmune oophoritis that resolved rapidly with no detectable lingering adverse effects on ovarian function. "
06/01/2011 - "Lack of complete disease protection suggests that other antigens may also play a role in autoimmune oophoritis. "
01/01/2001 - "While investigating this animal model we cloned a novel gene that encodes an ooplasm-specific antigen associated with autoimmune oophoritis in mice. "
12/01/1982 - "The results suggest that, in this post-thymectomy autoimmune oophoritis, NTx abrogates the Lyt-1 T cell subpopulation that serves as suppressive or regulatory cells over developing self-reactive cells directed toward ovarian antigens, and eventually may cause autoimmune oophoritis."
01/01/2022 - "We previously identified an oocyte-specific protein as a major antigen inciting autoimmune oophoritis in mice. "

05/01/1999 - "Moreover, since similar association of antiovarian antibodies has been observed in an experimental model of autoimmune oophoritis, our findings raise the possibility of autoimmune ovarian lesion in patients with SLE."
04/08/1989 - "[Autoimmune oophoritis and anti-ovarian antibodies]."
06/01/1980 - "Autoimmune oophoritis in thymectomized mice: detection of circulating antibodies against oocytes."
11/01/1989 - "The autoimmune oophoritis resulting from thymectomy at 3 days of age (Tx-3) in B6A female mice is characterized by dysgenic ovaries and circulating auto-antibodies against the oocyte (AOA). "
11/01/1980 - "Experimental autoimmune oophoritis characterized by rapid loss of oocytes with infiltration of lymphocytes and circulating anti-oocyte antibodies could be induced in (C57Bl/6Cr x A/JCr)F1 mice after thymectomy (Tx) at a critical age of 3 days (Tx-3) but not 0. "

01/01/1994 - "To be reversible, a ZP3 vaccine must not contain pathogenic T cell epitopes of ZP3, but contraception without autoimmune oophoritis may be feasible. "
07/01/1997 - "To avoid autoimmune oophoritis, synthetic peptides corresponding to B cell epitope(s) and devoid of oophoritogenic T cell epitopes as immunogens have been proposed. "
01/01/2000 - "To circumvent autoimmune oophoritis after immunization with zona pellucida (ZP) glycoproteins, synthetic peptides encompassing B cell epitope(s) and devoid of oophoritogenic T cell epitopes as immunogens have been proposed. "
03/01/1996 - "A ZP3 peptide contains both an autoimmune oophoritis-inducing T cell epitope and a B cell epitope that induces autoantibody to ZP. "
11/15/1993 - "A 13-mer peptide of the ZP3 glycoprotein from mouse zona pellucida has a T cell epitope that induces autoimmune oophoritis and a B cell epitope that reacts with antibody to murine ZP3. "

10/01/1995 - "Experimental murine autoimmune oophoritis, a model of human premature ovarian failure, is induced by immunization with a peptide of the ZP3 glycoprotein from mouse zona pellucida (ZP3(330-340)) in CFA. "
03/01/1996 - "Herein we show that blockage of glycoprotein (gp)39 and CD40 interaction with gp39 monoclonal antibody (mAb) results in the failure to induce both autoimmune oophoritis and autoantibody production. "
01/01/2000 - "To circumvent autoimmune oophoritis after immunization with zona pellucida (ZP) glycoproteins, synthetic peptides encompassing B cell epitope(s) and devoid of oophoritogenic T cell epitopes as immunogens have been proposed. "
11/15/1993 - "A 13-mer peptide of the ZP3 glycoprotein from mouse zona pellucida has a T cell epitope that induces autoimmune oophoritis and a B cell epitope that reacts with antibody to murine ZP3. "
11/01/1993 - "A nonamer peptide from murine nicotinic acetylcholine receptor delta chain (ACR delta), which shared four amino acid residues with a nonamer peptide of murine ovarian zona pellucida glycoprotein ZP3, induced murine autoimmune oophoritis and IgG autoantibody to the zona pellucida. "

07/01/1997 - "To avoid autoimmune oophoritis, synthetic peptides corresponding to B cell epitope(s) and devoid of oophoritogenic T cell epitopes as immunogens have been proposed. "
01/01/2000 - "To circumvent autoimmune oophoritis after immunization with zona pellucida (ZP) glycoproteins, synthetic peptides encompassing B cell epitope(s) and devoid of oophoritogenic T cell epitopes as immunogens have been proposed. "
03/01/1996 - "A ZP3 peptide contains both an autoimmune oophoritis-inducing T cell epitope and a B cell epitope that induces autoantibody to ZP. "
11/15/1993 - "A 13-mer peptide of the ZP3 glycoprotein from mouse zona pellucida has a T cell epitope that induces autoimmune oophoritis and a B cell epitope that reacts with antibody to murine ZP3. "

01/01/2002 - "The results are discussed in the context of complications of ZP-based human immunocontraceptive vaccines and case reports of human autoimmune oophoritis."
06/01/1994 - "Research in zona pellucida vaccine development must overcome the risk of immune damage to ovarian oocytes, subsequent development of autoimmune oophoritis, and disturbed ovarian function. "
12/01/1995 - "However, certain sequences of ZP proteins, when incorporated into the vaccine construct, activate CD4+ T cells of the recipient organism to direct a cellular immune attack (autoimmune oophoritis) to other functionally relevant ovarian components (primordial follicles, steroidogenic cells). "
01/01/1994 - "To be reversible, a ZP3 vaccine must not contain pathogenic T cell epitopes of ZP3, but contraception without autoimmune oophoritis may be feasible. "

09/01/1989 - "Recognition of this aspect of autoimmune oophoritis may help to prevent oophorectomy in patients whose functioning ovarian tissue is already compromised by autoimmune destruction."
09/01/1989 - "We have seen two additional patients with histologically verified autoimmune oophoritis who underwent diagnostic laparotomy and oophorectomy because of cystic enlargement of the ovaries. "

12/01/1982 - "Study on cellular events in post-thymectomy autoimmune oophoritis in mice. "
01/01/2022 - "We studied an animal model for human autoimmune POI in mice with autoimmune oophoritis induced by neonatal thymectomy performed at day 3 (TX3). "
01/01/2001 - "The neonatal-thymectomy-induced mouse model of autoimmune oophoritis has two important similarities with human autoimmune oophoritis. "
11/01/1997 - "Post-thymectomy murine experimental autoimmune oophoritis is associated with reduced natural killer cell activity."
06/01/1997 - "Thus, neonatal thymectomy abrogates the postnatal shift to a Th1-dominant pattern, and the resulting persistent neonatal-like Th2-dominant response is tightly associated with the development of postthymectomy autoimmune oophoritis. "

07/27/2023 - "A Systematic Review of Autoimmune Oophoritis Therapies."
09/01/2003 - "Autoimmune oophoritis, although apparently an uncommon cause of follicular dysfunction in these women, nonetheless presents the opportunity to develop an effective therapy to restore fertility. "

08/01/1995 - "Autoimmune oophoritis developed by 7 days after transplantation to the NTX3 mice. "

09/01/1989 - "We have seen two additional patients with histologically verified autoimmune oophoritis who underwent diagnostic laparotomy and oophorectomy because of cystic enlargement of the ovaries. "