Type 2 Cyclic Nucleotide Phosphodiesterases

A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC GMP.

Also Known As:

Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic GMP-Stimulated Phosphodiesterase; Cyclic Nucleotide Phosphodiesterase PDE2 Family; Cyclic Nucleotide Phosphodiesterases, Type 2A; PDE2 Phosphodiesterase; PDE2 Phosphodiesterases; Phosphodiesterase 2A; cGMP-Dependent 3',5'-Cyclic Phosphodiesterase; 3',5'-Cyclic Phosphodiesterase, cGMP-Dependent; Cyclic GMP Stimulated Phosphodiesterase; Phosphodiesterase, Cyclic GMP-Stimulated; cGMP Dependent 3',5' Cyclic Phosphodiesterase

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Diester Hydrolases: 2391
        3',5'-Cyclic-AMP Phosphodiesterases: 185
        Type 2 Cyclic Nucleotide Phosphodiesterases: 20
        3',5'-Cyclic-GMP Phosphodiesterases
        Type 2 Cyclic Nucleotide Phosphodiesterases: 20
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - 3',5'-Cyclic-AMP Phosphodiesterases: 185
      - Type 2 Cyclic Nucleotide Phosphodiesterases: 20
    - 3',5'-Cyclic-GMP Phosphodiesterases
      - Type 2 Cyclic Nucleotide Phosphodiesterases: 20

mouse Pde2a protein

Bio-Agent Context: Research Results