Bestrophins

A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.

Also Known As:

BEST-1 Protein; BEST-2 Protein; Bestrophin Family; Bestrophin Proteins; Bestrophin-1; Bestrophin-2; BEST 1 Protein; BEST 2 Protein; Bestrophin 1; Bestrophin 2; Bestrophin

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Chloride Channels: 1799
        Bestrophins: 100
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Ion Channels: 6731
        Chloride Channels: 1799
        Bestrophins: 100
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Chloride Channels: 1799
        Bestrophins: 100
  - Eye Proteins: 2
    - Bestrophins: 100

rat Best1 protein

Bio-Agent Context: Research Results