|1.||Piccardo, P: 1 article (01/2004)|
|2.||Shie, F-S: 1 article (01/2004)|
|3.||Zhou, Y: 1 article (01/2004)|
|4.||Montine, T J: 1 article (01/2004)|
|5.||Zhang, J: 1 article (01/2004)|
|6.||Ao, Mingfang: 1 article (01/2003)|
|7.||Amarnath, Venkataraman: 1 article (01/2003)|
|8.||Montine, Thomas J: 1 article (01/2003)|
|9.||Jing, Deqiang: 1 article (01/2003)|
|10.||Gu, Guangyu: 1 article (01/2003)|
|1.||Parkinsonian Disorders (Parkinsonism)
01/01/1996 - "Agricultural exposure to the organomanganese fungicide MANEB (manganese-ethylene-bis-dithiocarbamate) may induce an extrapyramidal syndrome resembling parkinsonism. "
08/01/1994 - "Permanent parkinsonism was observed in a man with chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate). "
08/01/1994 - "Parkinsonism after chronic exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate)."
04/01/1988 - "Two young agricultural workers with a parkinsonian syndrome, who mentioned exposure to the fungicide maneb (manganese ethylene-bis-dithiocarbamate), led us to investigate a new possible source of Mn intoxication. "
01/01/2003 - "After establishing this model, we tested whether Mn-EBDC provoked dopamine efflux in the striatum, a well-known phenomenon produced by the mitochondrial inhibitor 1-methyl-4-phenylpyridinium (MPP+), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that causes parkinsonism in humans, as well as in some animals. "
|2.||Parkinson Disease (Parkinson's Disease)
01/01/2004 - "To investigate the mechanisms underlying this neurodegeneration, we studied the effects of Mn-EBDC on proteasomal function, which is decreased in patients with Parkinson's disease (PD), in a dopaminergic neuronal cell line (MES 23.5 or MES). "
01/01/2004 - "Proteasomal inhibition induced by manganese ethylene-bis-dithiocarbamate: relevance to Parkinson's disease."
01/01/2003 - "Our data demonstrated that Mn-EBDC induced extensive striatal dopamine efflux that was comparable with that induced by MPP+, and that Mn-EBDC preferentially inhibited mitochondrial complex III. As mitochondrial dysfunction is pivotal in the pathogenesis of Parkinson's disease (PD), our results support the proposal that exposure to pesticides such as maneb, or other naturally occurring compounds that inhibit mitochondrial function, may contribute to PD development."
|3.||1-Methyl-4-phenylpyridinium (1 Methyl 4 phenylpyridinium)
|4.||1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
|5.||Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)