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1- (2'- amino- 3',3'- dimethylbutanoyl)pyrrolidine- 2- carbonitrile

FE-999011 is the (2S,2'S)-isomer; structure in first source

Also Known As:

FE 999011; FE-999011; FE999011

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitriles: 227
  - 1-(2'-amino-3',3'-dimethylbutanoyl)pyrrolidine-2-carbonitrile: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - 1-(2'-amino-3',3'-dimethylbutanoyl)pyrrolidine-2-carbonitrile: 1

Experts

1.	Ashworth, Doreen: 1 article (05/2002)
2.	Aubert, Michel L: 1 article (05/2002)
3.	Broqua, Pierre: 1 article (05/2002)
4.	Evans, D Michael: 1 article (05/2002)
5.	Haigh, Robert: 1 article (05/2002)
6.	Junien, Jean-Louis: 1 article (05/2002)
7.	Sudre, Béatrice: 1 article (05/2002)
8.	White, Richard B: 1 article (05/2002)

Related Diseases

1.	Glucose Intolerance 05/01/2002 - "This study demonstrates that DPP-IV inhibitors such as FE 999011 could be of clinical value to delay the progression from impaired glucose tolerance to type 2 diabetes."
2.	Type 2 Diabetes Mellitus (MODY) 05/01/2002 - "In the Zucker diabetic fatty (ZDF) rat, a rodent model of type 2 diabetes, chronic treatment with FE 999011 (10 mg/kg per os, once or twice a day) postponed the development of diabetes, with the twice-a-day treatment delaying the onset of hyperglycemia by 21 days. " 05/01/2002 - "This study demonstrates that DPP-IV inhibitors such as FE 999011 could be of clinical value to delay the progression from impaired glucose tolerance to type 2 diabetes."
3.	Hypertriglyceridemia 05/01/2002 - "In addition, treatment with FE 999011 stabilized food and water intake to prediabetic levels and reduced hypertriglyceridemia while preventing the rise in circulating free fatty acids. "
4.	Hyperglycemia 05/01/2002 - "In the Zucker diabetic fatty (ZDF) rat, a rodent model of type 2 diabetes, chronic treatment with FE 999011 (10 mg/kg per os, once or twice a day) postponed the development of diabetes, with the twice-a-day treatment delaying the onset of hyperglycemia by 21 days. "

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