|1.||Tack, Jan: 6 articles (03/2013 - 03/2011)|
|2.||Tack, J: 5 articles (01/2014 - 09/2008)|
|3.||Takei, Mineo: 4 articles (02/2014 - 03/2011)|
|4.||Kato, Hiroki: 3 articles (12/2014 - 06/2012)|
|5.||Tanaka, Takao: 3 articles (02/2014 - 03/2011)|
|6.||Matsunaga, Yugo: 3 articles (02/2014 - 03/2011)|
|7.||Kato, H: 3 articles (06/2012 - 03/2009)|
|8.||Yoshii, Kazuyoshi: 3 articles (11/2011 - 03/2011)|
|9.||Kawabata, Yoshihiro: 3 articles (11/2011 - 03/2011)|
|10.||Saito, Youichi: 2 articles (12/2014 - 06/2012)|
06/01/2012 - "Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real-time ultrasonography."
06/01/2010 - "Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia - 100 mg t.i.d. "
06/01/2012 - "Improvement in subjective symptoms has been reported in functional dyspepsia (FD) patients administered with acotiamide. "
06/01/2012 - "A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia."
10/01/2011 - "Acotiamide is a first-in-class drug with both prokinetic and fundus-relaxing properties that was evaluated in the recent phase 2 and phase 3 trials in functional dyspepsia. "
|4.||Ganglion Cysts (Ganglion)
03/01/2002 - "1. To study the mechanisms involved in the action of Z-338, a newly synthesized gastroprokinetic agent, experiments were performed with the paratracheal ganglion cells acutely dissociated from 2-week-old Wistar rats. "
03/01/2002 - "An electrophysiological study of muscarinic and nicotinic receptors of rat paratracheal ganglion neurons and their inhibition by Z-338."
03/01/2002 - "The effects of Z-338 on both nicotinic and muscarinic responses of the ganglion cells were studied by nystatin perforated patch recording configuration under the current- and voltage-clamp conditions. "
03/01/2002 - "4. The inhibitory actions of Z-338 on the membrane depolarization and corresponding inward currents mediated by M(1)-muscarinic and neuronal nicotinic ACh receptors in the isolated ganglion cells were discussed in relation to the inhibitory actions on autoreceptors in the parasympathetic nerve terminals, which would explain the gastroprokinetic actions of Z-338."
|5.||Gastroesophageal Reflux (GERD)
01/01/2015 - "Acotiamide, a novel gastrointestinal motility modulator, at a standard dose did not significantly affect esophageal motor functions or gastroesophageal reflux in healthy adults. "
01/01/2015 - "Effects of acotiamide on esophageal motor function and gastroesophageal reflux in healthy volunteers."
01/01/2015 - "In the present study, we evaluated the direct effects of acotiamide, a novel prokinetic agent for the treatment of functional dyspepsia, on esophageal motor function and gastroesophageal reflux. "
|3.||Proton Pumps (Proton Pump)
|8.||Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
|10.||gamma-Aminobutyric Acid (GABA)