|1.||Huang, Li-Yu: 2 articles (01/2015 - 08/2013)|
|2.||Han, Ze-Guang: 2 articles (01/2015 - 08/2013)|
|3.||Duma, Dariusz: 1 article (09/2015)|
|4.||Wojtysiak-Duma, Beata: 1 article (09/2015)|
|5.||Dabrowska, Anna Maria: 1 article (09/2015)|
|6.||Tarach, Jerzy Stanislaw: 1 article (09/2015)|
|7.||Wang, Shuo: 1 article (01/2015)|
|8.||Ye, Buqing: 1 article (01/2015)|
|9.||Fan, Zusen: 1 article (01/2015)|
|10.||Xiong, Zhen: 1 article (01/2015)|
07/01/1993 - "These studies thus suggest that one or more unique inhibitors of insulin receptor tyrosine kinase are present in fibroblasts of certain patients with severe insulin resistance. "
09/01/2015 - "It plays a role as a physiological inhibitor of insulin receptor tyrosine kinase associated with insulin resistance and a negative acute phase reactant. "
03/01/1998 - "In addition, in vitro overexpression of PC-1 in cultured cells induces insulin resistance associated with diminished insulin receptor tyrosine kinase activity. "
07/01/1997 - "This protein appears to act as an endogenous inhibitor of the insulin receptor tyrosine kinase which suggests that primary over-expression of PC-1 may play an aetiological role in some forms of insulin resistance. "
07/01/1997 - "Expression of the putative inhibitor of the insulin receptor tyrosine kinase PC-1 in dermal fibroblasts from patients with syndromes of severe insulin resistance."
03/01/1997 - "Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-alpha gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity."
03/01/1997 - "In the present study we measured PC-1 content, tumour necrosis factor (TNF)-alpha gene expression, and insulin stimulation of insulin receptor tyrosine-kinase activity in adipose tissue from non-obese, non-diabetic subjects. "
10/01/1997 - "Moreover, the overexpression (by two- to fourfold) of the cytokine tumour necrosis factor alpha (TNF alpha) in white adipose tissue, which may have a determinant role in the insulin resistance of the O mice, was unaffected by Mo. Likewise, overexpression of the ob gene in white adipose tissue was unchanged by Mo. In conclusion, Mo markedly improved glucose homeostasis in the ob/ob mice by an insulin-like action which appeared to be exerted distal to the insulin receptor tyrosine kinase step. "
01/01/2012 - "Hence, compounds that augment insulin receptor tyrosine kinase activity would be useful in the treatment of diabetes mellitus. "
03/01/1989 - "Liver insulin receptor tyrosine kinase activity in a rat model of type II diabetes mellitus and obesity."
01/01/2012 - "Molecular docking studies of banana flower flavonoids as insulin receptor tyrosine kinase activators as a cure for diabetes mellitus."
|4.||Hepatocellular Carcinoma (Hepatoma)
08/28/2013 - "Insulin receptor tyrosine kinase substrate (IRTKS) is closely associated with actin remodelling and membrane protrusion, but its role in the pathogenesis of malignant tumours, including hepatocellular carcinoma (HCC), is still unknown. "
08/28/2013 - "Insulin receptor tyrosine kinase substrate activates EGFR/ERK signalling pathway and promotes cell proliferation of hepatocellular carcinoma."
01/01/1991 - "Lipid-induced insulin resistance in cultured hepatoma cells is associated with a decreased insulin receptor tyrosine kinase activity."
10/06/1995 - "TNF effect on IRS-1 in Fao hepatoma cells was not associated with a significant reduction in insulin receptor tyrosine kinase activity as measured in vitro but impaired the association of IRS-1 with phosphatidylinositol 3-kinase, localizing TNF impact to IRS-1. "
05/01/1990 - "This Mr-185,000 protein whose phosphorylation was stimulated by ConA was identical to pp185, a protein reported previously to be a putative endogenous substrate for the insulin receptor tyrosine kinase in rat hepatoma cells. "
|5.||Type 2 Diabetes Mellitus (MODY)
09/01/1994 - "The impaired response of the insulin receptor tyrosine kinase which is found in NIDDM appears to contribute to the pathogenesis of the signalling defect. "
06/01/1994 - "Insulin-receptor tyrosine kinase activity is decreased in erythrocytes from non-obese patients with NIDDM."
01/01/1994 - "The impaired response of the insulin receptor tyrosine kinase, which is found in NIDDM, appears to contribute to the pathogenesis of the signalling defect. "
07/01/1993 - "Reduced insulin receptor tyrosine kinase activity and internalization have been reported in non-insulin-dependent diabetes mellitus (NIDDM) patients. "
07/01/1993 - "Relationship between insulin receptor tyrosine kinase activity and internalization in monocytes of non-insulin-dependent diabetes mellitus patients."
|2.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|4.||Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
|8.||Protein Kinase C
|10.||Membrane Glycoproteins (Membrane Glycoprotein)
|1.||Drug Therapy (Chemotherapy)