|1.||Falck, John R: 4 articles (07/2015 - 06/2007)|
|2.||Capdevila, Jorge H: 3 articles (07/2015 - 06/2007)|
|3.||Pollock, David M: 3 articles (03/2006 - 10/2003)|
|4.||Imig, John D: 3 articles (03/2006 - 10/2003)|
|5.||Zeldin, Darryl C: 2 articles (03/2014 - 10/2003)|
|6.||Imig, J D: 2 articles (09/2007 - 01/2007)|
|7.||Wang, Wenhui: 1 article (07/2015)|
|8.||Christmas, Peter: 1 article (01/2015)|
|9.||Capozzi, Megan E: 1 article (07/2014)|
|10.||Omelka, Radoslav: 1 article (07/2014)|
12/01/2009 - "The decrease in cyp2c expression and EETs levels in HO-2-null mice underscores the importance of the HO system in the regulation of epoxygenase levels and suggests that protection against obesity-induced cardiovascular complications requires interplay between these two systems. "
12/01/2009 - "The 7-month-old TSOD mice, which represented severe obesity/diabetes-related pathophysiology, showed higher expressions of Cyp2c and Cyp3a compared with TSNO mice, while those of Cyp1a and Cyp2e were lower. "
08/01/2004 - "Altered kidney CYP2C and cyclooxygenase-2 levels are associated with obesity-related albuminuria."
|2.||Cardiovascular Diseases (Cardiovascular Disease)
01/01/2005 - "Expression of CYP2C, CYP2E1, CYP3A4, and CYP3A5 in colon mucosa of normal and adenomatous colonic tissue of patients with adenoma and disease-free controls was determined by RT-PCR. "
01/01/2005 - "To estimate the role of cytochrome P450 in carcinogenesis of the colon, expression patterns and protein levels of four representative CYPs (CYP2C, CYP2E1, CYP3A4 and CYP3A5) were determined in colon mucosa of normal and adenomatous colonic tissue of patients with adenomas and disease-free controls. "
|4.||Hypertension (High Blood Pressure)
01/01/2007 - "Renal Cyp2c protein expression significantly decreased with ANG/HS hypertension in WT mice as compared to high salt alone. "
10/01/2003 - "These results support the hypothesis that angiotensin II infusion induces persistent salt-sensitive hypertension after withdrawal of angiotensin II that may be due to downregulation of CYP2C and CYP2J epoxygenases in renal microvessels."
01/01/2007 - "These data suggest that IL6, while having no effect on blood pressure, impairs regulation of epoxygenase producing Cyp2c, which could contribute to the development of renal injury in angiotensin salt-sensitive hypertension."
01/01/2007 - "Impaired cytochrome P450 epoxygenase enzyme (Cyp2c) regulation contributes to renal damage in angiotensin salt-sensitive hypertension (ANG/HS). "
03/01/2006 - "We hypothesized that the downregulation of Cyp2c by tumor necrosis factor (TNF) alpha contributes to hypertension and renal injury in salt-sensitive angiotensin hypertension. "
06/15/2007 - "Compared with untreated controls, Wy-14643-treated animals showed marked reductions in tumor growth and vascularization, which were accompanied by decreases in the plasma levels of pro-angiogenic epoxygenase metabolites (EETs), hepatic EET biosynthesis, and Cyp2c epoxygenase expression. "
01/01/2005 - "Immunohistochemical and western blotting analyses demonstrated that GS-positive, catnb-mutated tumors showed levels of CYP1A, CYP2B, CYP2C and CYP2E1, which were similar or slightly enhanced in comparison with non-tumoral liver tissue. "
02/01/2004 - "In summary, we have demonstrated that tumors of the breast express two out of four members of the CYP2C family, indicating that activation of such prodrugs as oxazaphosphorines may take place intratumorally. "
01/01/2003 - "CYP2B and CYP2C in the CP resistant tumor were inactive and only slightly induced by dexamethasone. "
06/15/2007 - "To study the role of the PPARalpha receptor and of its Cyp2c epoxygenase gene target in tumorigenesis, we treated mice injected with tumor cells with Wy-14,643, a PPARalpha-selective ligand. "
|1.||Cytochrome P-450 Enzyme System (Cytochrome P450)
|2.||Arachidonic Acid (Vitamin F)
|3.||Cytochrome P-450 CYP2E1 (CYP2E1)
|5.||Alkane 1-Monooxygenase (Alkane 1 Monooxygenase)
|6.||Mixed Function Oxygenases (Monooxygenases)
|8.||Vitamin A (Retinol)
|2.||Drug Therapy (Chemotherapy)